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Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers

The relation between the force (load) and the velocity of shortening (V) in contracting skeletal muscle is part of a rectangular hyperbola: (P + a) V = b(Po − P); where Po is the maximum isometric force and a and b are constants. The force–velocity (P–V) relation suggests that muscle can regulate it...

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Detalles Bibliográficos
Autores principales: Sugi, Haruo, Ohno, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627110/
https://www.ncbi.nlm.nih.gov/pubmed/31238505
http://dx.doi.org/10.3390/ijms20123075
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author Sugi, Haruo
Ohno, Tetsuo
author_facet Sugi, Haruo
Ohno, Tetsuo
author_sort Sugi, Haruo
collection PubMed
description The relation between the force (load) and the velocity of shortening (V) in contracting skeletal muscle is part of a rectangular hyperbola: (P + a) V = b(Po − P); where Po is the maximum isometric force and a and b are constants. The force–velocity (P–V) relation suggests that muscle can regulate its energy output depending on the load imposed on it (Hill, 1938). After the establishment of the sliding filament mechanism (H.E. Huxley and Hanson, 1954), the P–V relation has been regarded to reflect the cyclic interaction between myosin heads in myosin filaments and the corresponding myosin-binding sites in actin filaments, coupled with ATP hydrolysis (A.F. Huxley, 1957). In single skeletal muscle fibers, however, the P–V relation deviates from the hyperbola at the high force region, indicating complicated characteristics of the cyclic actin–myosin interaction. To correlate the P–V relation with kinetics of actin–myosin interaction, skinned muscle fibers have been developed, in which the surface membrane is removed to control chemical and ionic conditions around the 3D lattice of actin and myosin filaments. This article also deals with experimental methods with which the structural instability of skinned fibers can be overcome by applying parabolic decreases in fiber length.
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spelling pubmed-66271102019-07-19 Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers Sugi, Haruo Ohno, Tetsuo Int J Mol Sci Review The relation between the force (load) and the velocity of shortening (V) in contracting skeletal muscle is part of a rectangular hyperbola: (P + a) V = b(Po − P); where Po is the maximum isometric force and a and b are constants. The force–velocity (P–V) relation suggests that muscle can regulate its energy output depending on the load imposed on it (Hill, 1938). After the establishment of the sliding filament mechanism (H.E. Huxley and Hanson, 1954), the P–V relation has been regarded to reflect the cyclic interaction between myosin heads in myosin filaments and the corresponding myosin-binding sites in actin filaments, coupled with ATP hydrolysis (A.F. Huxley, 1957). In single skeletal muscle fibers, however, the P–V relation deviates from the hyperbola at the high force region, indicating complicated characteristics of the cyclic actin–myosin interaction. To correlate the P–V relation with kinetics of actin–myosin interaction, skinned muscle fibers have been developed, in which the surface membrane is removed to control chemical and ionic conditions around the 3D lattice of actin and myosin filaments. This article also deals with experimental methods with which the structural instability of skinned fibers can be overcome by applying parabolic decreases in fiber length. MDPI 2019-06-24 /pmc/articles/PMC6627110/ /pubmed/31238505 http://dx.doi.org/10.3390/ijms20123075 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sugi, Haruo
Ohno, Tetsuo
Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title_full Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title_fullStr Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title_full_unstemmed Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title_short Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers
title_sort physiological significance of the force-velocity relation in skeletal muscle and muscle fibers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627110/
https://www.ncbi.nlm.nih.gov/pubmed/31238505
http://dx.doi.org/10.3390/ijms20123075
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