Cargando…

FGF19–FGFR4 Signaling in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an increasing mortality rate. Aberrant expression of fibroblast growth factor 19–fibroblast growth factor receptor 4 (FGF19–FGFR4) is reported to be an oncogenic-driver pathway for HCC patients. Thus, the FGF19–FGFR4 signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raja, Aroosha, Park, Inkeun, Haq, Farhan, Ahn, Sung-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627123/ https://www.ncbi.nlm.nih.gov/pubmed/31167419 http://dx.doi.org/10.3390/cells8060536

Ejemplares similares

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib
por: Gao, Lixia, et al.
Publicado: (2017)

Genomic relevance of FGF14 and associated genes on the prognosis of pancreatic cancer
por: Raja, Aroosha, et al.
Publicado: (2021)

FGFR1 expression defines clinically distinct subtypes in pancreatic cancer
por: Haq, Farhan, et al.
Publicado: (2018)

FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention
por: Wang, Yijun, et al.
Publicado: (2021)

Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma
por: Repana, Dimitra, et al.
Publicado: (2015)

FGF/FGFR signaling in health and disease
por: Xie, Yangli, et al.
Publicado: (2020)

Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma
por: Shin, Ji-Yon, et al.
Publicado: (2021)

The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma
por: Kanzaki, Hiroaki, et al.
Publicado: (2021)

The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma
por: Ahn, Sung-Min, et al.
Publicado: (2018)

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
por: Yang, Chaofeng, et al.
Publicado: (2012)

Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment
por: Liu, Guihong, et al.
Publicado: (2021)

Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
por: Ruan, Ruiwen, et al.
Publicado: (2023)

A Network Map of FGF-1/FGFR Signaling System
por: Raju, Rajesh, et al.
Publicado: (2014)

Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal Adenocarcinomas
por: Jomrich, Gerd, et al.
Publicado: (2019)

FGF/FGFR signaling pathway involved resistance in various cancer types
por: Zhou, Yangyang, et al.
Publicado: (2020)

Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression
por: Liu, Yanan, et al.
Publicado: (2020)

FGF/FGFR signaling in adrenocortical development and tumorigenesis: novel potential therapeutic targets in adrenocortical carcinoma
por: Tamburello, Mariangela, et al.
Publicado: (2022)

Multi-organ FGF21-FGFR1 signaling in metabolic health and disease
por: Kaur, Namrita, et al.
Publicado: (2022)

Genomic Relevance of FGFR2 on the Prognosis of HCV-Induced Hepatocellular Carcinoma Patients
por: Khan, Walizeb, et al.
Publicado: (2022)

Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models
por: Su, Nan, et al.
Publicado: (2014)

Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice
por: Yu, Youxi, et al.
Publicado: (2021)

Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
por: Zhang, Jinglin, et al.
Publicado: (2019)

FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation
por: Zhao, Huakan, et al.
Publicado: (2015)

FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma
por: Tao, Zhanchao, et al.
Publicado: (2022)

Melatonin Suppresses Oral Squamous Cell Carcinomas Migration and Invasion through Blocking FGF19/FGFR 4 Signaling Pathway
por: Wang, Leilei, et al.
Publicado: (2021)

Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
por: Wiedlocha, Antoni, et al.
Publicado: (2021)

Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis
por: Wu, Xinle, et al.
Publicado: (2009)

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
por: Agrawal, Archita, et al.
Publicado: (2018)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
por: Astolfi, Annalisa, et al.
Publicado: (2020)

FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models
por: Rajendran, Ranjithkumar, et al.
Publicado: (2021)

FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis
por: Lang, Liwei, et al.
Publicado: (2021)

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230
por: Blackwell, Christina, et al.
Publicado: (2016)

FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System
por: Chu, Wei-Chen, et al.
Publicado: (2013)

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible
por: Grabner, Alexander, et al.
Publicado: (2017)

The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives
por: Santolla, Maria Francesca, et al.
Publicado: (2020)

Exploring the FGF/FGFR System in Ocular Tumors: New Insights and Perspectives
por: Loda, Alessandra, et al.
Publicado: (2022)

Interaction of FGF9 with FGFR3‐IIIb/IIIc, a putative driver of growth and aggressive behaviour of hepatocellular carcinoma
por: Paur, Jakob, et al.
Publicado: (2020)

Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling
por: Hosaka, Kayoko, et al.
Publicado: (2018)

Inhibition of FGFR Signaling by Targeting FGF/FGFR Extracellular Interactions: Towards the Comprehension of the Molecular Mechanism through NMR Approaches
por: Pagano, Katiuscia, et al.
Publicado: (2022)

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance
por: Szymczyk, Jakub, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g7i9i2r0c97t2oibo51ofedlhr