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Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy

The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has invigorated the focus on the discovery and development of novel treatment options. The discovery and investigation of essential mycobacterial targets is of utmost importance. In addition to the discovery of nov...

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Autores principales: Torfs, Eveline, Piller, Tatiana, Cos, Paul, Cappoen, Davie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627145/
https://www.ncbi.nlm.nih.gov/pubmed/31212777
http://dx.doi.org/10.3390/ijms20122868
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author Torfs, Eveline
Piller, Tatiana
Cos, Paul
Cappoen, Davie
author_facet Torfs, Eveline
Piller, Tatiana
Cos, Paul
Cappoen, Davie
author_sort Torfs, Eveline
collection PubMed
description The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has invigorated the focus on the discovery and development of novel treatment options. The discovery and investigation of essential mycobacterial targets is of utmost importance. In addition to the discovery of novel targets, focusing on non-lethal pathways and the use of host-directed therapies has gained interest. These adjunctive treatment options could not only lead to increased antibiotic susceptibility of Mycobacterium tuberculosis, but also have the potential to avoid the emergence of drug resistance. Host-directed therapies, on the other hand, can also reduce the associated lung pathology and improve disease outcome. This review will provide an outline of recent opportunities.
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spelling pubmed-66271452019-07-19 Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy Torfs, Eveline Piller, Tatiana Cos, Paul Cappoen, Davie Int J Mol Sci Review The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has invigorated the focus on the discovery and development of novel treatment options. The discovery and investigation of essential mycobacterial targets is of utmost importance. In addition to the discovery of novel targets, focusing on non-lethal pathways and the use of host-directed therapies has gained interest. These adjunctive treatment options could not only lead to increased antibiotic susceptibility of Mycobacterium tuberculosis, but also have the potential to avoid the emergence of drug resistance. Host-directed therapies, on the other hand, can also reduce the associated lung pathology and improve disease outcome. This review will provide an outline of recent opportunities. MDPI 2019-06-12 /pmc/articles/PMC6627145/ /pubmed/31212777 http://dx.doi.org/10.3390/ijms20122868 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Torfs, Eveline
Piller, Tatiana
Cos, Paul
Cappoen, Davie
Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title_full Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title_fullStr Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title_full_unstemmed Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title_short Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy
title_sort opportunities for overcoming mycobacterium tuberculosis drug resistance: emerging mycobacterial targets and host-directed therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627145/
https://www.ncbi.nlm.nih.gov/pubmed/31212777
http://dx.doi.org/10.3390/ijms20122868
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