Cargando…

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

The ubiquitin proteasome system (UPS) plays an important role in regulating numerous cellular processes, and a dysfunctional UPS is thought to contribute to motor neuron disease. Consequently, we sought to map the changing ubiquitome in human iPSCs during their pluripotent stage and following differ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bax, Monique, McKenna, Jessie, Do-Ha, Dzung, Stevens, Claire H., Higginbottom, Sarah, Balez, Rachelle, Cabral-da-Silva, Mauricio e Castro, Farrawell, Natalie E., Engel, Martin, Poronnik, Philip, Yerbury, Justin J., Saunders, Darren N., Ooi, Lezanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627164/ https://www.ncbi.nlm.nih.gov/pubmed/31200561 http://dx.doi.org/10.3390/cells8060581

Ejemplares similares

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis
por: Farrawell, Natalie E, et al.
Publicado: (2023)

Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide
por: Balez, Rachelle, et al.
Publicado: (2016)

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling
por: Muñoz, Sonia Sanz, et al.
Publicado: (2020)

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
por: Balez, Rachelle, et al.
Publicado: (2016)

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver
por: Nagarajan, Shilpa R., et al.
Publicado: (2017)

Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver
por: Nagarajan, Shilpa R., et al.
Publicado: (2017)

Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?
por: Chisholm, Christen G., et al.
Publicado: (2022)

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS
por: Farrawell, Natalie E., et al.
Publicado: (2020)

Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research
por: Engel, Martin, et al.
Publicado: (2016)

Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry
por: Bruinen, Anne L., et al.
Publicado: (2018)

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
por: San Gil, Rebecca, et al.
Publicado: (2017)

Mutant Cu/Zn Superoxide Dismutase (A4V) Turnover Is Altered in Cells Containing Inclusions
por: Farrawell, Natalie E., et al.
Publicado: (2021)

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions
por: Farrawell, Natalie E., et al.
Publicado: (2015)

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation
por: Zeineddine, Rafaa, et al.
Publicado: (2015)

The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia
por: Shearer, Robert F., et al.
Publicado: (2018)

Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice
por: Beamish, Sarah B., et al.
Publicado: (2022)

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
por: Ooi, Lezanne, et al.
Publicado: (2020)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

Production of Infectious Dengue Virus in Aedes aegypti Is Dependent on the Ubiquitin Proteasome Pathway
por: Choy, Milly M., et al.
Publicado: (2015)

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis
por: Davidson, Jennilee M., et al.
Publicado: (2023)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis
por: Buskila, Yossi, et al.
Publicado: (2019)

Poxvirus Exploitation of the Ubiquitin-Proteasome System
por: Barry, Michele, et al.
Publicado: (2010)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
por: Ernst, Robert, et al.
Publicado: (2011)

The ubiquitin-proteasome system in Alzheimer's disease
por: Oddo, Salvatore
Publicado: (2008)

Autoregulation of the 26S proteasome by in situ ubiquitination
por: Jacobson, Andrew D., et al.
Publicado: (2014)

Ubiquitin Proteasome System in Stress and Disease
por: Karpov, Dmitry, et al.
Publicado: (2012)

Intracellular Dynamics of the Ubiquitin-Proteasome-System
por: Chowdhury, Maisha, et al.
Publicado: (2015)

Ubiquitin-Proteasome System in Neurodegenerative Disorders
por: Rao, Geeta, et al.
Publicado: (2015)

The Ubiquitin–Proteasome System in Immune Cells
por: Çetin, Gonca, et al.
Publicado: (2021)

Ubiquitin-proteasome system in diabetic retinopathy
por: Svikle, Zane, et al.
Publicado: (2022)

Copper homeostasis and the ubiquitin proteasome system
por: Zhang, Bichao, et al.
Publicado: (2023)

The Ubiquitin–Proteasome System in Tumor Metabolism
por: Wang, Jie, et al.
Publicado: (2023)

The role of the ubiquitination-proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer
por: Orlowski, Robert Z, et al.
Publicado: (2003)

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems
por: Amelio, Ivano, et al.
Publicado: (2015)

Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants
por: Su, Tong, et al.
Publicado: (2020)

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
por: Bedford, Lynn, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_s33pc1fflkaiegt9ti2so105ao