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Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases

Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate...

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Detalles Bibliográficos
Autores principales: Madzharova, Elizabeta, Kastl, Philipp, Sabino, Fabio, auf dem Keller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627178/
https://www.ncbi.nlm.nih.gov/pubmed/31238509
http://dx.doi.org/10.3390/ijms20123077
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author Madzharova, Elizabeta
Kastl, Philipp
Sabino, Fabio
auf dem Keller, Ulrich
author_facet Madzharova, Elizabeta
Kastl, Philipp
Sabino, Fabio
auf dem Keller, Ulrich
author_sort Madzharova, Elizabeta
collection PubMed
description Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate intra- and extracellular pathways and networks. Thereby, they are functionally implicated in the regulation of multiple physiological and pathological processes. Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs, which suggests an important role of PTMs in modulating the pleiotropic activities of these proteases. This review summarizes the recent progress towards understanding the role of PTMs (glycosylation, phosphorylation, glycosaminoglycans) on the activity of several members of the MMP family.
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spelling pubmed-66271782019-07-19 Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases Madzharova, Elizabeta Kastl, Philipp Sabino, Fabio auf dem Keller, Ulrich Int J Mol Sci Review Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate intra- and extracellular pathways and networks. Thereby, they are functionally implicated in the regulation of multiple physiological and pathological processes. Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs, which suggests an important role of PTMs in modulating the pleiotropic activities of these proteases. This review summarizes the recent progress towards understanding the role of PTMs (glycosylation, phosphorylation, glycosaminoglycans) on the activity of several members of the MMP family. MDPI 2019-06-24 /pmc/articles/PMC6627178/ /pubmed/31238509 http://dx.doi.org/10.3390/ijms20123077 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Madzharova, Elizabeta
Kastl, Philipp
Sabino, Fabio
auf dem Keller, Ulrich
Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title_full Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title_fullStr Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title_full_unstemmed Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title_short Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
title_sort post-translational modification-dependent activity of matrix metalloproteinases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627178/
https://www.ncbi.nlm.nih.gov/pubmed/31238509
http://dx.doi.org/10.3390/ijms20123077
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