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Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of no...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627191/ https://www.ncbi.nlm.nih.gov/pubmed/31208049 http://dx.doi.org/10.3390/cells8060592 |
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author | Leupold, Dieter Szyc, Lukasz Stankovic, Goran Strobel, Sabrina Völker, Hans-Ullrich Fleck, Ulrike Müller, Thomas Scholz, Matthias Riederer, Peter Monoranu, Camelia-Maria |
author_facet | Leupold, Dieter Szyc, Lukasz Stankovic, Goran Strobel, Sabrina Völker, Hans-Ullrich Fleck, Ulrike Müller, Thomas Scholz, Matthias Riederer, Peter Monoranu, Camelia-Maria |
author_sort | Leupold, Dieter |
collection | PubMed |
description | Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of nonlinear spectroscopy, based on a stepwise two-photon excitation. Cutaneous pigmentation and postmortem neuromelanin of Parkinson patients were characterized by fluorescence spectra and compared with controls. Spectral differences could not be documented, implying that there is neither a Parkinson fingerprint in cutaneous melanin spectra nor a melanin-associated fingerprint indicating an increased melanoma risk. Our measurements suggest that Parkinson’s disease occurs without a configuration change of neuromelanin. However, Parkinson patients displayed the same dermatofluorescence spectroscopic fingerprint of a local malignant transformation as controls. This is the first comparative retrospective fluorescence analysis of cutaneous melanin and postmortem neuromelanin based on nonlinear spectroscopy in patients with Parkinson’s disease and controls, and this method is a very suitable diagnostic tool for melanoma screening and early detection in Parkinson patients. Our results suggest a non-pigmentary pathway as the main link between Parkinson’s disease and melanoma, and they do not rule out the melanocortin-1-receptor gene as an additional bridge between both diseases. |
format | Online Article Text |
id | pubmed-6627191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66271912019-07-19 Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma Leupold, Dieter Szyc, Lukasz Stankovic, Goran Strobel, Sabrina Völker, Hans-Ullrich Fleck, Ulrike Müller, Thomas Scholz, Matthias Riederer, Peter Monoranu, Camelia-Maria Cells Article Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of nonlinear spectroscopy, based on a stepwise two-photon excitation. Cutaneous pigmentation and postmortem neuromelanin of Parkinson patients were characterized by fluorescence spectra and compared with controls. Spectral differences could not be documented, implying that there is neither a Parkinson fingerprint in cutaneous melanin spectra nor a melanin-associated fingerprint indicating an increased melanoma risk. Our measurements suggest that Parkinson’s disease occurs without a configuration change of neuromelanin. However, Parkinson patients displayed the same dermatofluorescence spectroscopic fingerprint of a local malignant transformation as controls. This is the first comparative retrospective fluorescence analysis of cutaneous melanin and postmortem neuromelanin based on nonlinear spectroscopy in patients with Parkinson’s disease and controls, and this method is a very suitable diagnostic tool for melanoma screening and early detection in Parkinson patients. Our results suggest a non-pigmentary pathway as the main link between Parkinson’s disease and melanoma, and they do not rule out the melanocortin-1-receptor gene as an additional bridge between both diseases. MDPI 2019-06-15 /pmc/articles/PMC6627191/ /pubmed/31208049 http://dx.doi.org/10.3390/cells8060592 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leupold, Dieter Szyc, Lukasz Stankovic, Goran Strobel, Sabrina Völker, Hans-Ullrich Fleck, Ulrike Müller, Thomas Scholz, Matthias Riederer, Peter Monoranu, Camelia-Maria Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title | Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title_full | Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title_fullStr | Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title_full_unstemmed | Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title_short | Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma |
title_sort | melanin and neuromelanin fluorescence studies focusing on parkinson’s disease and its inherent risk for melanoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627191/ https://www.ncbi.nlm.nih.gov/pubmed/31208049 http://dx.doi.org/10.3390/cells8060592 |
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