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Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma

Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of no...

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Autores principales: Leupold, Dieter, Szyc, Lukasz, Stankovic, Goran, Strobel, Sabrina, Völker, Hans-Ullrich, Fleck, Ulrike, Müller, Thomas, Scholz, Matthias, Riederer, Peter, Monoranu, Camelia-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627191/
https://www.ncbi.nlm.nih.gov/pubmed/31208049
http://dx.doi.org/10.3390/cells8060592
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author Leupold, Dieter
Szyc, Lukasz
Stankovic, Goran
Strobel, Sabrina
Völker, Hans-Ullrich
Fleck, Ulrike
Müller, Thomas
Scholz, Matthias
Riederer, Peter
Monoranu, Camelia-Maria
author_facet Leupold, Dieter
Szyc, Lukasz
Stankovic, Goran
Strobel, Sabrina
Völker, Hans-Ullrich
Fleck, Ulrike
Müller, Thomas
Scholz, Matthias
Riederer, Peter
Monoranu, Camelia-Maria
author_sort Leupold, Dieter
collection PubMed
description Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of nonlinear spectroscopy, based on a stepwise two-photon excitation. Cutaneous pigmentation and postmortem neuromelanin of Parkinson patients were characterized by fluorescence spectra and compared with controls. Spectral differences could not be documented, implying that there is neither a Parkinson fingerprint in cutaneous melanin spectra nor a melanin-associated fingerprint indicating an increased melanoma risk. Our measurements suggest that Parkinson’s disease occurs without a configuration change of neuromelanin. However, Parkinson patients displayed the same dermatofluorescence spectroscopic fingerprint of a local malignant transformation as controls. This is the first comparative retrospective fluorescence analysis of cutaneous melanin and postmortem neuromelanin based on nonlinear spectroscopy in patients with Parkinson’s disease and controls, and this method is a very suitable diagnostic tool for melanoma screening and early detection in Parkinson patients. Our results suggest a non-pigmentary pathway as the main link between Parkinson’s disease and melanoma, and they do not rule out the melanocortin-1-receptor gene as an additional bridge between both diseases.
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spelling pubmed-66271912019-07-19 Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma Leupold, Dieter Szyc, Lukasz Stankovic, Goran Strobel, Sabrina Völker, Hans-Ullrich Fleck, Ulrike Müller, Thomas Scholz, Matthias Riederer, Peter Monoranu, Camelia-Maria Cells Article Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of nonlinear spectroscopy, based on a stepwise two-photon excitation. Cutaneous pigmentation and postmortem neuromelanin of Parkinson patients were characterized by fluorescence spectra and compared with controls. Spectral differences could not be documented, implying that there is neither a Parkinson fingerprint in cutaneous melanin spectra nor a melanin-associated fingerprint indicating an increased melanoma risk. Our measurements suggest that Parkinson’s disease occurs without a configuration change of neuromelanin. However, Parkinson patients displayed the same dermatofluorescence spectroscopic fingerprint of a local malignant transformation as controls. This is the first comparative retrospective fluorescence analysis of cutaneous melanin and postmortem neuromelanin based on nonlinear spectroscopy in patients with Parkinson’s disease and controls, and this method is a very suitable diagnostic tool for melanoma screening and early detection in Parkinson patients. Our results suggest a non-pigmentary pathway as the main link between Parkinson’s disease and melanoma, and they do not rule out the melanocortin-1-receptor gene as an additional bridge between both diseases. MDPI 2019-06-15 /pmc/articles/PMC6627191/ /pubmed/31208049 http://dx.doi.org/10.3390/cells8060592 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leupold, Dieter
Szyc, Lukasz
Stankovic, Goran
Strobel, Sabrina
Völker, Hans-Ullrich
Fleck, Ulrike
Müller, Thomas
Scholz, Matthias
Riederer, Peter
Monoranu, Camelia-Maria
Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title_full Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title_fullStr Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title_full_unstemmed Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title_short Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma
title_sort melanin and neuromelanin fluorescence studies focusing on parkinson’s disease and its inherent risk for melanoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627191/
https://www.ncbi.nlm.nih.gov/pubmed/31208049
http://dx.doi.org/10.3390/cells8060592
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