Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma

DOT1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged leukemia. Inhibitors have been developed to target DOT1L activity in leukemia, but cellular mechanisms that regulate DOT1L are still poorly understood. We have identified the histone deacetylase Rpd3 as a negative regulator...

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Detalles Bibliográficos
Autores principales: Vlaming, Hanneke, McLean, Chelsea M, Korthout, Tessy, Alemdehy, Mir Farshid, Hendriks, Sjoerd, Lancini, Cesare, Palit, Sander, Klarenbeek, Sjoerd, Kwesi‐Maliepaard, Eliza Mari, Molenaar, Thom M, Hoekman, Liesbeth, Schmidlin, Thierry T, Altelaar, AF Maarten, van Welsem, Tibor, Dannenberg, Jan‐Hermen, Jacobs, Heinz, van Leeuwen, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627229/
https://www.ncbi.nlm.nih.gov/pubmed/31304633
http://dx.doi.org/10.15252/embj.2019101564

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