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Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient

INTRODUCTION: Angiomyofibroblastoma is a rare benign myofibroblastic neoplasm which mainly occurs in the soft tissues of the pelvi-perineal region of females. AIM: To present an unusual case of angiomyofibroblastoma mimicking an inguinal hernia in a 62-year-old male. MATERIAL AND METHODS: The patien...

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Autores principales: Banias, Laura, Gurzu, Simona, Jung, Ioan, Borz, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627251/
https://www.ncbi.nlm.nih.gov/pubmed/31320858
http://dx.doi.org/10.5114/ada.2019.84597
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author Banias, Laura
Gurzu, Simona
Jung, Ioan
Borz, Cristian
author_facet Banias, Laura
Gurzu, Simona
Jung, Ioan
Borz, Cristian
author_sort Banias, Laura
collection PubMed
description INTRODUCTION: Angiomyofibroblastoma is a rare benign myofibroblastic neoplasm which mainly occurs in the soft tissues of the pelvi-perineal region of females. AIM: To present an unusual case of angiomyofibroblastoma mimicking an inguinal hernia in a 62-year-old male. MATERIAL AND METHODS: The patient was hospitalized with an irreducible, painless inguinal mass and surgical intervention for inguinal hernia was decided. The well-defined nodular mass was sent for histological examination. RESULTS: Under microscope, proliferation of spindle and oval cells around thin-walled vessels was observed, being intermingled with mature adipocytes. We did not identify necrosis, haemorrhage, cytologic atypia or mitotic figures. The tumour cells displayed positivity for desmin, vimentin, CD34, oestrogen and progesterone receptors, a low Ki67 index and unusual nuclear positivity for c-theta (PKCθ). They were negative for smooth muscle actin (SMA), S100, CD44, maspin, synaptophysin, DOG1 and CD117. The case was diagnosed as angiomyofibroblastoma, the main challenge being the differential diagnosis with aggressive angiomyxoma, which can present a similar histologic aspect and immunophenotype and recurs more frequently. No recurrences were observed 8 months after the surgery. CONCLUSIONS: Angiomyofibroblastoma should be included in the differential diagnosis of inguinal hernia. This is the fourteenth case of angiomyofibroblastoma diagnosed in males.
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spelling pubmed-66272512019-07-18 Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient Banias, Laura Gurzu, Simona Jung, Ioan Borz, Cristian Postepy Dermatol Alergol Original Paper INTRODUCTION: Angiomyofibroblastoma is a rare benign myofibroblastic neoplasm which mainly occurs in the soft tissues of the pelvi-perineal region of females. AIM: To present an unusual case of angiomyofibroblastoma mimicking an inguinal hernia in a 62-year-old male. MATERIAL AND METHODS: The patient was hospitalized with an irreducible, painless inguinal mass and surgical intervention for inguinal hernia was decided. The well-defined nodular mass was sent for histological examination. RESULTS: Under microscope, proliferation of spindle and oval cells around thin-walled vessels was observed, being intermingled with mature adipocytes. We did not identify necrosis, haemorrhage, cytologic atypia or mitotic figures. The tumour cells displayed positivity for desmin, vimentin, CD34, oestrogen and progesterone receptors, a low Ki67 index and unusual nuclear positivity for c-theta (PKCθ). They were negative for smooth muscle actin (SMA), S100, CD44, maspin, synaptophysin, DOG1 and CD117. The case was diagnosed as angiomyofibroblastoma, the main challenge being the differential diagnosis with aggressive angiomyxoma, which can present a similar histologic aspect and immunophenotype and recurs more frequently. No recurrences were observed 8 months after the surgery. CONCLUSIONS: Angiomyofibroblastoma should be included in the differential diagnosis of inguinal hernia. This is the fourteenth case of angiomyofibroblastoma diagnosed in males. Termedia Publishing House 2019-05-14 2019-04 /pmc/articles/PMC6627251/ /pubmed/31320858 http://dx.doi.org/10.5114/ada.2019.84597 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Banias, Laura
Gurzu, Simona
Jung, Ioan
Borz, Cristian
Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title_full Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title_fullStr Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title_full_unstemmed Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title_short Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
title_sort angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627251/
https://www.ncbi.nlm.nih.gov/pubmed/31320858
http://dx.doi.org/10.5114/ada.2019.84597
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