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Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster
Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627286/ https://www.ncbi.nlm.nih.gov/pubmed/31226868 http://dx.doi.org/10.3390/brainsci9060146 |
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author | Sheerin, Christina M. Kovalchick, Laurel V. Overstreet, Cassie Rappaport, Lance M. Williamson, Vernell Vladimirov, Vladimir Ruggiero, Kenneth J. Amstadter, Ananda B. |
author_facet | Sheerin, Christina M. Kovalchick, Laurel V. Overstreet, Cassie Rappaport, Lance M. Williamson, Vernell Vladimirov, Vladimir Ruggiero, Kenneth J. Amstadter, Ananda B. |
author_sort | Sheerin, Christina M. |
collection | PubMed |
description | Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are underrepresented in genetic studies. In an epidemiologic sample tornado-exposed adolescents (n = 707, 51% female, M(age) = 14.54 years), trajectories of PTSD symptoms were examined at baseline and at 4-months and 12-months following baseline. This study aimed to determine if rare genetic variation in genes previously found in the sample to be related to PTSD diagnosis at baseline (MPHOSPH9, LGALS13, SLC2A2), environmental factors (disaster severity, social support), or their interplay were associated with symptom trajectories. A series of mixed effects models were conducted. Symptoms decreased over the three time points. Elevated tornado severity was associated with elevated baseline symptoms. Elevated recreational support was associated with lower baseline symptoms and attenuated improvement over time. Greater LGLAS13 variants attenuated symptom improvement over time. An interaction between MPHOSPH9 variants and tornado severity was associated with elevated baseline symptoms, but not change over time. Findings suggest the importance of rare genetic variation and environmental factors on the longitudinal course of PTSD symptoms following natural disaster trauma exposure. |
format | Online Article Text |
id | pubmed-6627286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66272862019-07-23 Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster Sheerin, Christina M. Kovalchick, Laurel V. Overstreet, Cassie Rappaport, Lance M. Williamson, Vernell Vladimirov, Vladimir Ruggiero, Kenneth J. Amstadter, Ananda B. Brain Sci Article Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are underrepresented in genetic studies. In an epidemiologic sample tornado-exposed adolescents (n = 707, 51% female, M(age) = 14.54 years), trajectories of PTSD symptoms were examined at baseline and at 4-months and 12-months following baseline. This study aimed to determine if rare genetic variation in genes previously found in the sample to be related to PTSD diagnosis at baseline (MPHOSPH9, LGALS13, SLC2A2), environmental factors (disaster severity, social support), or their interplay were associated with symptom trajectories. A series of mixed effects models were conducted. Symptoms decreased over the three time points. Elevated tornado severity was associated with elevated baseline symptoms. Elevated recreational support was associated with lower baseline symptoms and attenuated improvement over time. Greater LGLAS13 variants attenuated symptom improvement over time. An interaction between MPHOSPH9 variants and tornado severity was associated with elevated baseline symptoms, but not change over time. Findings suggest the importance of rare genetic variation and environmental factors on the longitudinal course of PTSD symptoms following natural disaster trauma exposure. MDPI 2019-06-20 /pmc/articles/PMC6627286/ /pubmed/31226868 http://dx.doi.org/10.3390/brainsci9060146 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sheerin, Christina M. Kovalchick, Laurel V. Overstreet, Cassie Rappaport, Lance M. Williamson, Vernell Vladimirov, Vladimir Ruggiero, Kenneth J. Amstadter, Ananda B. Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title | Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title_full | Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title_fullStr | Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title_full_unstemmed | Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title_short | Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster |
title_sort | genetic and environmental predictors of adolescent ptsd symptom trajectories following a natural disaster |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627286/ https://www.ncbi.nlm.nih.gov/pubmed/31226868 http://dx.doi.org/10.3390/brainsci9060146 |
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