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Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity

Background: Non-Celiac Wheat Sensitivity (NCWS) is still a largely undefined condition, due to the lack of a diagnostic marker. Few data are available about the nutritional characteristics of NCWS patients at diagnosis. Aims: To evaluate the proportion of NCWS patients who were underweight, normal w...

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Autores principales: Mansueto, Pasquale, Soresi, Maurizio, La Blasca, Francesco, Fayer, Francesca, D’Alcamo, Alberto, Carroccio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627298/
https://www.ncbi.nlm.nih.gov/pubmed/31146428
http://dx.doi.org/10.3390/nu11061220
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author Mansueto, Pasquale
Soresi, Maurizio
La Blasca, Francesco
Fayer, Francesca
D’Alcamo, Alberto
Carroccio, Antonio
author_facet Mansueto, Pasquale
Soresi, Maurizio
La Blasca, Francesco
Fayer, Francesca
D’Alcamo, Alberto
Carroccio, Antonio
author_sort Mansueto, Pasquale
collection PubMed
description Background: Non-Celiac Wheat Sensitivity (NCWS) is still a largely undefined condition, due to the lack of a diagnostic marker. Few data are available about the nutritional characteristics of NCWS patients at diagnosis. Aims: To evaluate the proportion of NCWS patients who were underweight, normal weight, overweight, or obese at diagnosis, and to search for possible correlations between their Body Mass Index (BMI) and other NCWS-related disease characteristics. Patients and Methods: The clinical charts of 145 NCWS patients (125 F, 20 M, mean age 37.1 ± 11.4 years), diagnosed between January 2012 and March 2018, were reviewed. As a comparison, 84 celiac disease (CD) patients (73 F, 11 M, mean age 39.8 ± 13.9 years) were evaluated. All NCWS diagnoses were based on a double-blind placebo-controlled wheat challenge (DBPCWC) method. Results: BMI distribution was similar in the NCWS (6.2% underweight and 15.2% obese subjects) and CD patients (6% underweight and 7.1% obese subjects). Underweight NCWS subjects were significantly younger and had a shorter clinical history than the overweight or obese ones. Unlike the other NCWS patients, none of them had a DQ2 and/or DQ8 haplotype. Overweight and obese NCWS patients were more frequently suffering from associated autoimmune diseases than the other BMI categories (P = 0.05). Compared to the CD controls, NCWS patients showed a higher frequency of Irritable Bowel Syndrome (IBS)-like (P = 0.01) and extraintestinal symptoms (P = 0.03) and a longer clinical history (P = 0.04), whereas weight loss was more frequent in CD (P = 0.02). Conclusions: NCWS patients showed a BMI distribution similar to CD patients. However, NCWS was found to be a heterogenous condition that regards BMI, and clinical characteristics differed between the underweight and overweight/obese patients.
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spelling pubmed-66272982019-07-23 Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity Mansueto, Pasquale Soresi, Maurizio La Blasca, Francesco Fayer, Francesca D’Alcamo, Alberto Carroccio, Antonio Nutrients Article Background: Non-Celiac Wheat Sensitivity (NCWS) is still a largely undefined condition, due to the lack of a diagnostic marker. Few data are available about the nutritional characteristics of NCWS patients at diagnosis. Aims: To evaluate the proportion of NCWS patients who were underweight, normal weight, overweight, or obese at diagnosis, and to search for possible correlations between their Body Mass Index (BMI) and other NCWS-related disease characteristics. Patients and Methods: The clinical charts of 145 NCWS patients (125 F, 20 M, mean age 37.1 ± 11.4 years), diagnosed between January 2012 and March 2018, were reviewed. As a comparison, 84 celiac disease (CD) patients (73 F, 11 M, mean age 39.8 ± 13.9 years) were evaluated. All NCWS diagnoses were based on a double-blind placebo-controlled wheat challenge (DBPCWC) method. Results: BMI distribution was similar in the NCWS (6.2% underweight and 15.2% obese subjects) and CD patients (6% underweight and 7.1% obese subjects). Underweight NCWS subjects were significantly younger and had a shorter clinical history than the overweight or obese ones. Unlike the other NCWS patients, none of them had a DQ2 and/or DQ8 haplotype. Overweight and obese NCWS patients were more frequently suffering from associated autoimmune diseases than the other BMI categories (P = 0.05). Compared to the CD controls, NCWS patients showed a higher frequency of Irritable Bowel Syndrome (IBS)-like (P = 0.01) and extraintestinal symptoms (P = 0.03) and a longer clinical history (P = 0.04), whereas weight loss was more frequent in CD (P = 0.02). Conclusions: NCWS patients showed a BMI distribution similar to CD patients. However, NCWS was found to be a heterogenous condition that regards BMI, and clinical characteristics differed between the underweight and overweight/obese patients. MDPI 2019-05-29 /pmc/articles/PMC6627298/ /pubmed/31146428 http://dx.doi.org/10.3390/nu11061220 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mansueto, Pasquale
Soresi, Maurizio
La Blasca, Francesco
Fayer, Francesca
D’Alcamo, Alberto
Carroccio, Antonio
Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title_full Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title_fullStr Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title_full_unstemmed Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title_short Body Mass Index and Associated Clinical Variables in Patients with Non-Celiac Wheat Sensitivity
title_sort body mass index and associated clinical variables in patients with non-celiac wheat sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627298/
https://www.ncbi.nlm.nih.gov/pubmed/31146428
http://dx.doi.org/10.3390/nu11061220
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