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Effects of Estrogens on Platelets and Megakaryocytes
In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass. While platelets are central players in thrombus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627332/ https://www.ncbi.nlm.nih.gov/pubmed/31242705 http://dx.doi.org/10.3390/ijms20123111 |
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author | Dupuis, Marion Severin, Sonia Noirrit-Esclassan, Emmanuelle Arnal, Jean-François Payrastre, Bernard Valéra, Marie-Cécile |
author_facet | Dupuis, Marion Severin, Sonia Noirrit-Esclassan, Emmanuelle Arnal, Jean-François Payrastre, Bernard Valéra, Marie-Cécile |
author_sort | Dupuis, Marion |
collection | PubMed |
description | In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass. While platelets are central players in thrombus constitution, their implication in women treated with estrogens remains incompletely characterized. Platelets and their medullar progenitors, megakaryocytes, express estrogen receptors (ER) that may explain, at least in part, a sensitivity to hormonal changes. The purpose of this review is to summarize our current knowledge of estrogen actions on platelets and megakaryocytes in mice following in vivo administration and in women using MHT. |
format | Online Article Text |
id | pubmed-6627332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66273322019-07-23 Effects of Estrogens on Platelets and Megakaryocytes Dupuis, Marion Severin, Sonia Noirrit-Esclassan, Emmanuelle Arnal, Jean-François Payrastre, Bernard Valéra, Marie-Cécile Int J Mol Sci Review In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass. While platelets are central players in thrombus constitution, their implication in women treated with estrogens remains incompletely characterized. Platelets and their medullar progenitors, megakaryocytes, express estrogen receptors (ER) that may explain, at least in part, a sensitivity to hormonal changes. The purpose of this review is to summarize our current knowledge of estrogen actions on platelets and megakaryocytes in mice following in vivo administration and in women using MHT. MDPI 2019-06-25 /pmc/articles/PMC6627332/ /pubmed/31242705 http://dx.doi.org/10.3390/ijms20123111 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dupuis, Marion Severin, Sonia Noirrit-Esclassan, Emmanuelle Arnal, Jean-François Payrastre, Bernard Valéra, Marie-Cécile Effects of Estrogens on Platelets and Megakaryocytes |
title | Effects of Estrogens on Platelets and Megakaryocytes |
title_full | Effects of Estrogens on Platelets and Megakaryocytes |
title_fullStr | Effects of Estrogens on Platelets and Megakaryocytes |
title_full_unstemmed | Effects of Estrogens on Platelets and Megakaryocytes |
title_short | Effects of Estrogens on Platelets and Megakaryocytes |
title_sort | effects of estrogens on platelets and megakaryocytes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627332/ https://www.ncbi.nlm.nih.gov/pubmed/31242705 http://dx.doi.org/10.3390/ijms20123111 |
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