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Mechanisms behind Temsirolimus Resistance Causing Reactivated Growth and Invasive Behavior of Bladder Cancer Cells In Vitro

Background: Although mechanistic target of rapamycin (mTOR) inhibitors, such as temsirolimus, show promise in treating bladder cancer, acquired resistance often hampers efficacy. This study evaluates mechanisms leading to resistance. Methods: Cell growth, proliferation, cell cycle phases, and cell c...

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Detalles Bibliográficos
Autores principales:	Juengel, Eva, Natsheh, Iyad, Najafi, Ramin, Rutz, Jochen, Tsaur, Igor, Haferkamp, Axel, Chun, Felix K.-H., Blaheta, Roman A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627393/ https://www.ncbi.nlm.nih.gov/pubmed/31167517 http://dx.doi.org/10.3390/cancers11060777

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