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Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study

Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We condu...

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Autores principales: Panizza, Chloe E., Lim, Unhee, Yonemori, Kim M., Cassel, Kevin D., Wilkens, Lynne R., Harvie, Michelle N., Maskarinec, Gertraud, Delp, Edward J., Lampe, Johanna W., Shepherd, John A., Le Marchand, Loïc, Boushey, Carol J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627434/
https://www.ncbi.nlm.nih.gov/pubmed/31226790
http://dx.doi.org/10.3390/nu11061386
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author Panizza, Chloe E.
Lim, Unhee
Yonemori, Kim M.
Cassel, Kevin D.
Wilkens, Lynne R.
Harvie, Michelle N.
Maskarinec, Gertraud
Delp, Edward J.
Lampe, Johanna W.
Shepherd, John A.
Le Marchand, Loïc
Boushey, Carol J.
author_facet Panizza, Chloe E.
Lim, Unhee
Yonemori, Kim M.
Cassel, Kevin D.
Wilkens, Lynne R.
Harvie, Michelle N.
Maskarinec, Gertraud
Delp, Edward J.
Lampe, Johanna W.
Shepherd, John A.
Le Marchand, Loïc
Boushey, Carol J.
author_sort Panizza, Chloe E.
collection PubMed
description Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot study to demonstrate feasibility and explore efficacy of following IER+MED for 12 weeks to reduce VAT among East Asians in Hawaii. Sixty volunteers (aged 35–55, BMI 25–40 kg/m(2), VAT ≥ 90 cm(2) for men and ≥ 80 cm(2) for women) were randomized to IER+MED (two consecutive days with 70% energy restriction and 5 days euenergetic MED) or an active comparator (euenergetic Dietary Approaches to Stop Hypertension (DASH) diet). Participants and clinic staff (except dietitians) were blinded to group assignments. IER+MED had significantly larger reductions in DXA-measured VAT and total fat mass (−22.6 ± 3.6 cm(2) and −3.3 ± 0.4 kg, respectively) vs. DASH (−10.7 ± 3.5 cm(2) and −1.6 ± 0.4 kg) (p = 0.02 and p = 0.005). However, after adjusting for total fat mass, change in VAT was not statistically different between groups; whereas, improvement in alanine transaminase remained significantly greater for IER+MED vs. DASH (−16.2 ± 3.8 U/L vs. −4.0 ± 3.6 U/L, respectively, p = 0.02). Attrition rate was 10%, and participants adhered well to study prescriptions with no reported major adverse effect. Results demonstrate IER+MED is acceptable, lowers visceral and total adiposity among East Asian Americans, and may improve liver function more effectively than a healthful diet pattern. ClinicalTrials.gov Identifier: NCT03639350.
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spelling pubmed-66274342019-07-23 Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study Panizza, Chloe E. Lim, Unhee Yonemori, Kim M. Cassel, Kevin D. Wilkens, Lynne R. Harvie, Michelle N. Maskarinec, Gertraud Delp, Edward J. Lampe, Johanna W. Shepherd, John A. Le Marchand, Loïc Boushey, Carol J. Nutrients Article Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot study to demonstrate feasibility and explore efficacy of following IER+MED for 12 weeks to reduce VAT among East Asians in Hawaii. Sixty volunteers (aged 35–55, BMI 25–40 kg/m(2), VAT ≥ 90 cm(2) for men and ≥ 80 cm(2) for women) were randomized to IER+MED (two consecutive days with 70% energy restriction and 5 days euenergetic MED) or an active comparator (euenergetic Dietary Approaches to Stop Hypertension (DASH) diet). Participants and clinic staff (except dietitians) were blinded to group assignments. IER+MED had significantly larger reductions in DXA-measured VAT and total fat mass (−22.6 ± 3.6 cm(2) and −3.3 ± 0.4 kg, respectively) vs. DASH (−10.7 ± 3.5 cm(2) and −1.6 ± 0.4 kg) (p = 0.02 and p = 0.005). However, after adjusting for total fat mass, change in VAT was not statistically different between groups; whereas, improvement in alanine transaminase remained significantly greater for IER+MED vs. DASH (−16.2 ± 3.8 U/L vs. −4.0 ± 3.6 U/L, respectively, p = 0.02). Attrition rate was 10%, and participants adhered well to study prescriptions with no reported major adverse effect. Results demonstrate IER+MED is acceptable, lowers visceral and total adiposity among East Asian Americans, and may improve liver function more effectively than a healthful diet pattern. ClinicalTrials.gov Identifier: NCT03639350. MDPI 2019-06-20 /pmc/articles/PMC6627434/ /pubmed/31226790 http://dx.doi.org/10.3390/nu11061386 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Panizza, Chloe E.
Lim, Unhee
Yonemori, Kim M.
Cassel, Kevin D.
Wilkens, Lynne R.
Harvie, Michelle N.
Maskarinec, Gertraud
Delp, Edward J.
Lampe, Johanna W.
Shepherd, John A.
Le Marchand, Loïc
Boushey, Carol J.
Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title_full Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title_fullStr Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title_full_unstemmed Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title_short Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
title_sort effects of intermittent energy restriction combined with a mediterranean diet on reducing visceral adiposity: a randomized active comparator pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627434/
https://www.ncbi.nlm.nih.gov/pubmed/31226790
http://dx.doi.org/10.3390/nu11061386
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