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Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity

Brain–computer interfaces (BCIs), operated in a cue-based (offline) or self-paced (online) mode, can be used for inducing cortical plasticity for stroke rehabilitation by the pairing of movement-related brain activity with peripheral electrical stimulation. The aim of this study was to compare the d...

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Autores principales: Jochumsen, Mads, Navid, Muhammad Samran, Nedergaard, Rasmus Wiberg, Signal, Nada, Rashid, Usman, Hassan, Ali, Haavik, Heidi, Taylor, Denise, Niazi, Imran Khan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627467/
https://www.ncbi.nlm.nih.gov/pubmed/31159454
http://dx.doi.org/10.3390/brainsci9060127
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author Jochumsen, Mads
Navid, Muhammad Samran
Nedergaard, Rasmus Wiberg
Signal, Nada
Rashid, Usman
Hassan, Ali
Haavik, Heidi
Taylor, Denise
Niazi, Imran Khan
author_facet Jochumsen, Mads
Navid, Muhammad Samran
Nedergaard, Rasmus Wiberg
Signal, Nada
Rashid, Usman
Hassan, Ali
Haavik, Heidi
Taylor, Denise
Niazi, Imran Khan
author_sort Jochumsen, Mads
collection PubMed
description Brain–computer interfaces (BCIs), operated in a cue-based (offline) or self-paced (online) mode, can be used for inducing cortical plasticity for stroke rehabilitation by the pairing of movement-related brain activity with peripheral electrical stimulation. The aim of this study was to compare the difference in cortical plasticity induced by the two BCI modes. Fifteen healthy participants participated in two experimental sessions: cue-based BCI and self-paced BCI. In both sessions, imagined dorsiflexions were extracted from continuous electroencephalogram (EEG) and paired 50 times with the electrical stimulation of the common peroneal nerve. Before, immediately after, and 30 min after each intervention, the cortical excitability was measured through the motor-evoked potentials (MEPs) of tibialis anterior elicited through transcranial magnetic stimulation. Linear mixed regression models showed that the MEP amplitudes increased significantly (p < 0.05) from pre- to post- and 30-min post-intervention in terms of both the absolute and relative units, regardless of the intervention type. Compared to pre-interventions, the absolute MEP size increased by 79% in post- and 68% in 30-min post-intervention in the self-paced mode (with a true positive rate of ~75%), and by 37% in post- and 55% in 30-min post-intervention in the cue-based mode. The two modes were significantly different (p = 0.03) at post-intervention (relative units) but were similar at both post timepoints (absolute units). These findings suggest that immediate changes in cortical excitability may have implications for stroke rehabilitation, where it could be used as a priming protocol in conjunction with another intervention; however, the findings need to be validated in studies involving stroke patients.
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spelling pubmed-66274672019-07-23 Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity Jochumsen, Mads Navid, Muhammad Samran Nedergaard, Rasmus Wiberg Signal, Nada Rashid, Usman Hassan, Ali Haavik, Heidi Taylor, Denise Niazi, Imran Khan Brain Sci Article Brain–computer interfaces (BCIs), operated in a cue-based (offline) or self-paced (online) mode, can be used for inducing cortical plasticity for stroke rehabilitation by the pairing of movement-related brain activity with peripheral electrical stimulation. The aim of this study was to compare the difference in cortical plasticity induced by the two BCI modes. Fifteen healthy participants participated in two experimental sessions: cue-based BCI and self-paced BCI. In both sessions, imagined dorsiflexions were extracted from continuous electroencephalogram (EEG) and paired 50 times with the electrical stimulation of the common peroneal nerve. Before, immediately after, and 30 min after each intervention, the cortical excitability was measured through the motor-evoked potentials (MEPs) of tibialis anterior elicited through transcranial magnetic stimulation. Linear mixed regression models showed that the MEP amplitudes increased significantly (p < 0.05) from pre- to post- and 30-min post-intervention in terms of both the absolute and relative units, regardless of the intervention type. Compared to pre-interventions, the absolute MEP size increased by 79% in post- and 68% in 30-min post-intervention in the self-paced mode (with a true positive rate of ~75%), and by 37% in post- and 55% in 30-min post-intervention in the cue-based mode. The two modes were significantly different (p = 0.03) at post-intervention (relative units) but were similar at both post timepoints (absolute units). These findings suggest that immediate changes in cortical excitability may have implications for stroke rehabilitation, where it could be used as a priming protocol in conjunction with another intervention; however, the findings need to be validated in studies involving stroke patients. MDPI 2019-06-01 /pmc/articles/PMC6627467/ /pubmed/31159454 http://dx.doi.org/10.3390/brainsci9060127 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jochumsen, Mads
Navid, Muhammad Samran
Nedergaard, Rasmus Wiberg
Signal, Nada
Rashid, Usman
Hassan, Ali
Haavik, Heidi
Taylor, Denise
Niazi, Imran Khan
Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title_full Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title_fullStr Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title_full_unstemmed Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title_short Self-Paced Online vs. Cue-Based Offline Brain–Computer Interfaces for Inducing Neural Plasticity
title_sort self-paced online vs. cue-based offline brain–computer interfaces for inducing neural plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627467/
https://www.ncbi.nlm.nih.gov/pubmed/31159454
http://dx.doi.org/10.3390/brainsci9060127
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