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Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors
[Image: see text] Multivalent carbohydrate-based ligands were synthesized and evaluated as inhibitors of the adhesion protein HA of the influenza A virus (IAV). HA relies on multivalency for strong viral adhesion. While viral adhesion inhibition by large polymeric molecules has proven viable, limite...
Autores principales: | Lu, Wenjing, Du, Wenjuan, Somovilla, Victor J., Yu, Guangyun, Haksar, Diksha, de Vries, Erik, Boons, Geert-Jan, de Vries, Robert P., de Haan, Cornelis A. M., Pieters, Roland J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627469/ https://www.ncbi.nlm.nih.gov/pubmed/31251606 http://dx.doi.org/10.1021/acs.jmedchem.9b00303 |
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