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Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection
Context: Seaweed metabolites (fucoidans, carrageenans, ulvans, lectins, and polyphenols) are biologically active compounds that target proteins or genes of the influenza virus and host components that are necessary for replication and reproduction of the virus. Objective: This review gathers the inf...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627559/ https://www.ncbi.nlm.nih.gov/pubmed/31234532 http://dx.doi.org/10.3390/md17060373 |
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author | Besednova, Natalia Zaporozhets, Tatiana Kuznetsova, Tatiana Makarenkova, Ilona Fedyanina, Lydmila Kryzhanovsky, Sergey Malyarenko, Olesya Ermakova, Svetlana |
author_facet | Besednova, Natalia Zaporozhets, Tatiana Kuznetsova, Tatiana Makarenkova, Ilona Fedyanina, Lydmila Kryzhanovsky, Sergey Malyarenko, Olesya Ermakova, Svetlana |
author_sort | Besednova, Natalia |
collection | PubMed |
description | Context: Seaweed metabolites (fucoidans, carrageenans, ulvans, lectins, and polyphenols) are biologically active compounds that target proteins or genes of the influenza virus and host components that are necessary for replication and reproduction of the virus. Objective: This review gathers the information available in the literature regarding to the useful properties of seaweeds metabolites as potential agents for the prevention and therapy of influenza infection. Materials and methods: The sources of scientific literature were found in various electronic databases (i.e., PubMed, Web of Science, and ScienceDirect) and library search. The retrospective search depth is 25 years. Results: Influenza is a serious medical and social problem for humanity. Recently developed drugs are quite effective against currently circulating influenza virus strains, but their use can lead to the selection of resistant viral strains. In this regard, new therapeutic approaches and drugs with a broad spectrum of activity are needed. Metabolites of seaweeds fulfill these requirements. This review presents the results of in vitro and in vivo experimental and clinical studies about the effectiveness of these compounds in combating influenza infection and explains the necessity of their use as a potential basis for the creation of new drugs with a broad spectrum of activity. |
format | Online Article Text |
id | pubmed-6627559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66275592019-07-23 Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection Besednova, Natalia Zaporozhets, Tatiana Kuznetsova, Tatiana Makarenkova, Ilona Fedyanina, Lydmila Kryzhanovsky, Sergey Malyarenko, Olesya Ermakova, Svetlana Mar Drugs Review Context: Seaweed metabolites (fucoidans, carrageenans, ulvans, lectins, and polyphenols) are biologically active compounds that target proteins or genes of the influenza virus and host components that are necessary for replication and reproduction of the virus. Objective: This review gathers the information available in the literature regarding to the useful properties of seaweeds metabolites as potential agents for the prevention and therapy of influenza infection. Materials and methods: The sources of scientific literature were found in various electronic databases (i.e., PubMed, Web of Science, and ScienceDirect) and library search. The retrospective search depth is 25 years. Results: Influenza is a serious medical and social problem for humanity. Recently developed drugs are quite effective against currently circulating influenza virus strains, but their use can lead to the selection of resistant viral strains. In this regard, new therapeutic approaches and drugs with a broad spectrum of activity are needed. Metabolites of seaweeds fulfill these requirements. This review presents the results of in vitro and in vivo experimental and clinical studies about the effectiveness of these compounds in combating influenza infection and explains the necessity of their use as a potential basis for the creation of new drugs with a broad spectrum of activity. MDPI 2019-06-22 /pmc/articles/PMC6627559/ /pubmed/31234532 http://dx.doi.org/10.3390/md17060373 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Besednova, Natalia Zaporozhets, Tatiana Kuznetsova, Tatiana Makarenkova, Ilona Fedyanina, Lydmila Kryzhanovsky, Sergey Malyarenko, Olesya Ermakova, Svetlana Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title | Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title_full | Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title_fullStr | Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title_full_unstemmed | Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title_short | Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection |
title_sort | metabolites of seaweeds as potential agents for the prevention and therapy of influenza infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627559/ https://www.ncbi.nlm.nih.gov/pubmed/31234532 http://dx.doi.org/10.3390/md17060373 |
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