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Towards a Food Pharmacy: Immunologic Modulation through Diet

Patients frequently wonder whether their dietary pattern influences the course of inflammatory bowel disease (IBD). Many patients even avoid certain foods that aggravate their symptoms. Although interest in nutritional interventions is rising among physicians, the current application of nutritional...

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Detalles Bibliográficos
Autores principales: Molendijk, Ilse, van der Marel, Sander, Maljaars, P.W. Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627620/
https://www.ncbi.nlm.nih.gov/pubmed/31159179
http://dx.doi.org/10.3390/nu11061239
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author Molendijk, Ilse
van der Marel, Sander
Maljaars, P.W. Jeroen
author_facet Molendijk, Ilse
van der Marel, Sander
Maljaars, P.W. Jeroen
author_sort Molendijk, Ilse
collection PubMed
description Patients frequently wonder whether their dietary pattern influences the course of inflammatory bowel disease (IBD). Many patients even avoid certain foods that aggravate their symptoms. Although interest in nutritional interventions is rising among physicians, the current application of nutritional interventions in the IBD population is limited due to the lack of scientific evidence from clinical trials. Several studies, however, have identified associations between diet, gut microbiota, intestinal epithelial integrity, and mucosal immune responses. In patients consuming predominantly a Western diet high in n-6 poly-unsaturated fatty acids (PUFAs), sugars, and meat, and low in fruits and vegetables, an impaired gut epithelial barrier and disturbances in the intestinal microbiota have been observed, resulting in a chronic mucosal inflammation. An anti-inflammatory diet may restore this disbalance. In this review, we discuss the effects of diet on the composition of the microbiota, the gut epithelial barrier function, and the mucosal immune system.
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spelling pubmed-66276202019-07-23 Towards a Food Pharmacy: Immunologic Modulation through Diet Molendijk, Ilse van der Marel, Sander Maljaars, P.W. Jeroen Nutrients Review Patients frequently wonder whether their dietary pattern influences the course of inflammatory bowel disease (IBD). Many patients even avoid certain foods that aggravate their symptoms. Although interest in nutritional interventions is rising among physicians, the current application of nutritional interventions in the IBD population is limited due to the lack of scientific evidence from clinical trials. Several studies, however, have identified associations between diet, gut microbiota, intestinal epithelial integrity, and mucosal immune responses. In patients consuming predominantly a Western diet high in n-6 poly-unsaturated fatty acids (PUFAs), sugars, and meat, and low in fruits and vegetables, an impaired gut epithelial barrier and disturbances in the intestinal microbiota have been observed, resulting in a chronic mucosal inflammation. An anti-inflammatory diet may restore this disbalance. In this review, we discuss the effects of diet on the composition of the microbiota, the gut epithelial barrier function, and the mucosal immune system. MDPI 2019-05-31 /pmc/articles/PMC6627620/ /pubmed/31159179 http://dx.doi.org/10.3390/nu11061239 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Molendijk, Ilse
van der Marel, Sander
Maljaars, P.W. Jeroen
Towards a Food Pharmacy: Immunologic Modulation through Diet
title Towards a Food Pharmacy: Immunologic Modulation through Diet
title_full Towards a Food Pharmacy: Immunologic Modulation through Diet
title_fullStr Towards a Food Pharmacy: Immunologic Modulation through Diet
title_full_unstemmed Towards a Food Pharmacy: Immunologic Modulation through Diet
title_short Towards a Food Pharmacy: Immunologic Modulation through Diet
title_sort towards a food pharmacy: immunologic modulation through diet
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627620/
https://www.ncbi.nlm.nih.gov/pubmed/31159179
http://dx.doi.org/10.3390/nu11061239
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