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Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors
Background: Angiogenesis inhibitors (AIs) have become established as an effective cancer treatment. Whereas their interactions with antineoplastic drugs have extensively been investigated, little is known of the effect of their co-administration with nutraceuticals/dietary supplements (N/DSs), which...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627675/ https://www.ncbi.nlm.nih.gov/pubmed/31151284 http://dx.doi.org/10.3390/cells8060522 |
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author | Di Francia, Raffaele Berretta, Massimiliano Benincasa, Giulio D’Avino, Alfredo Facchini, Sergio Costagliola, Domenico Rossi, Paola |
author_facet | Di Francia, Raffaele Berretta, Massimiliano Benincasa, Giulio D’Avino, Alfredo Facchini, Sergio Costagliola, Domenico Rossi, Paola |
author_sort | Di Francia, Raffaele |
collection | PubMed |
description | Background: Angiogenesis inhibitors (AIs) have become established as an effective cancer treatment. Whereas their interactions with antineoplastic drugs have extensively been investigated, little is known of the effect of their co-administration with nutraceuticals/dietary supplements (N/DSs), which are often self-prescribed. N/DSs comprise a wide range of products such as herbs, nutrients, vitamins, minerals, and probiotics. Assessment of their interactions with cancer drugs, particularly AIs, is hampered by the difficulty of gauging the amount of active substances patients actually take. Moreover, there is no agreement on which approach should be used to determine which N/DSs are most likely to influence AI treatment efficacy. We present a comprehensive review of the metabolic routes of the major AIs and their possible interactions with N/DSs. Methods: The PubMed and Cochrane databases were searched for papers describing the metabolic routes of the main AIs and N/DSs. Results: Data from the 133 studies thus identified were used to compile a diagnostic table reporting known and expected AI-N/DS interactions based on their metabolization pathways. AIs and N/DSs sharing the cytochrome P450 pathway are at risk of negative interactions. Conclusions: Recent advances in pharmacogenetics offer exceptional opportunities to identify prognostic and predictive markers to enhance the efficacy of individualized AI treatments. The table provides a guide to genotyping patients who are due to receive AIs and is a promising tool to prevent occult AI-N/DS interactions in poor metabolizers. N/DS use by cancer patients receiving AIs is a topical problem requiring urgent attention from the scientific community. |
format | Online Article Text |
id | pubmed-6627675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66276752019-07-23 Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors Di Francia, Raffaele Berretta, Massimiliano Benincasa, Giulio D’Avino, Alfredo Facchini, Sergio Costagliola, Domenico Rossi, Paola Cells Review Background: Angiogenesis inhibitors (AIs) have become established as an effective cancer treatment. Whereas their interactions with antineoplastic drugs have extensively been investigated, little is known of the effect of their co-administration with nutraceuticals/dietary supplements (N/DSs), which are often self-prescribed. N/DSs comprise a wide range of products such as herbs, nutrients, vitamins, minerals, and probiotics. Assessment of their interactions with cancer drugs, particularly AIs, is hampered by the difficulty of gauging the amount of active substances patients actually take. Moreover, there is no agreement on which approach should be used to determine which N/DSs are most likely to influence AI treatment efficacy. We present a comprehensive review of the metabolic routes of the major AIs and their possible interactions with N/DSs. Methods: The PubMed and Cochrane databases were searched for papers describing the metabolic routes of the main AIs and N/DSs. Results: Data from the 133 studies thus identified were used to compile a diagnostic table reporting known and expected AI-N/DS interactions based on their metabolization pathways. AIs and N/DSs sharing the cytochrome P450 pathway are at risk of negative interactions. Conclusions: Recent advances in pharmacogenetics offer exceptional opportunities to identify prognostic and predictive markers to enhance the efficacy of individualized AI treatments. The table provides a guide to genotyping patients who are due to receive AIs and is a promising tool to prevent occult AI-N/DS interactions in poor metabolizers. N/DS use by cancer patients receiving AIs is a topical problem requiring urgent attention from the scientific community. MDPI 2019-05-30 /pmc/articles/PMC6627675/ /pubmed/31151284 http://dx.doi.org/10.3390/cells8060522 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Francia, Raffaele Berretta, Massimiliano Benincasa, Giulio D’Avino, Alfredo Facchini, Sergio Costagliola, Domenico Rossi, Paola Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title_full | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title_fullStr | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title_full_unstemmed | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title_short | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors |
title_sort | pharmacogenetic-based interactions between nutraceuticals and angiogenesis inhibitors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627675/ https://www.ncbi.nlm.nih.gov/pubmed/31151284 http://dx.doi.org/10.3390/cells8060522 |
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