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Metabolic Syndrome in Arab Adults with Low Bone Mineral Density

There are discrepancies in the reports on the association of metabolic syndrome (MetS) and its components with bone mineral density (BMD) and hence more population-based studies on this subject are needed. In this context, this observational study was aimed to investigate the association between T-s...

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Autores principales: Wani, Kaiser, Yakout, Sobhy M., Ansari, Mohammed Ghouse Ahmed, Sabico, Shaun, Hussain, Syed Danish, Alokail, Majed S., Sheshah, Eman, Aljohani, Naji J., Al-Saleh, Yousef, Reginster, Jean-Yves, Al-Daghri, Nasser M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627685/
https://www.ncbi.nlm.nih.gov/pubmed/31234393
http://dx.doi.org/10.3390/nu11061405
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author Wani, Kaiser
Yakout, Sobhy M.
Ansari, Mohammed Ghouse Ahmed
Sabico, Shaun
Hussain, Syed Danish
Alokail, Majed S.
Sheshah, Eman
Aljohani, Naji J.
Al-Saleh, Yousef
Reginster, Jean-Yves
Al-Daghri, Nasser M.
author_facet Wani, Kaiser
Yakout, Sobhy M.
Ansari, Mohammed Ghouse Ahmed
Sabico, Shaun
Hussain, Syed Danish
Alokail, Majed S.
Sheshah, Eman
Aljohani, Naji J.
Al-Saleh, Yousef
Reginster, Jean-Yves
Al-Daghri, Nasser M.
author_sort Wani, Kaiser
collection PubMed
description There are discrepancies in the reports on the association of metabolic syndrome (MetS) and its components with bone mineral density (BMD) and hence more population-based studies on this subject are needed. In this context, this observational study was aimed to investigate the association between T-scores of BMD at lumbar L1–L4 and full MetS and its individual components. A total of 1587 participants (84.7% females), >35 years and with risk factors associated with bone loss were recruited from February 2013 to August 2016. BMD was done at L1–L4 using dual-energy X-ray absorptiometry (DXA). T-Scores were calculated. Fasting blood samples and anthropometrics were done at recruitment. Fasting lipid profile and glucose were measured. Screening for full MetS and its components was done according to the National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria. Logistic regression analysis revealed that the odds of having full MetS increased significantly from the lowest T-score tertile to the highest one in both sexes (OR, odd ratio (95% CI, confidence interval) of tertile 2 and 3 at 1.49 (0.8 to 2.8) and 2.46 (1.3 to 4.7), p = 0.02 in males and 1.35 (1.0 to 1.7) and 1.45 (1.1 to1.9), p < 0.01 in females). The odds remained significant even after adjustments with age, body mass index (BMI), and other risk factors associated with bone loss. Among the components of MetS, only central obesity showed a significant positive association with T-score. The study suggests a significant positive association of T-score (spine) with full MetS irrespective of sex, and among the components of MetS this positive association was seen specifically with central obesity.
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spelling pubmed-66276852019-07-23 Metabolic Syndrome in Arab Adults with Low Bone Mineral Density Wani, Kaiser Yakout, Sobhy M. Ansari, Mohammed Ghouse Ahmed Sabico, Shaun Hussain, Syed Danish Alokail, Majed S. Sheshah, Eman Aljohani, Naji J. Al-Saleh, Yousef Reginster, Jean-Yves Al-Daghri, Nasser M. Nutrients Article There are discrepancies in the reports on the association of metabolic syndrome (MetS) and its components with bone mineral density (BMD) and hence more population-based studies on this subject are needed. In this context, this observational study was aimed to investigate the association between T-scores of BMD at lumbar L1–L4 and full MetS and its individual components. A total of 1587 participants (84.7% females), >35 years and with risk factors associated with bone loss were recruited from February 2013 to August 2016. BMD was done at L1–L4 using dual-energy X-ray absorptiometry (DXA). T-Scores were calculated. Fasting blood samples and anthropometrics were done at recruitment. Fasting lipid profile and glucose were measured. Screening for full MetS and its components was done according to the National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria. Logistic regression analysis revealed that the odds of having full MetS increased significantly from the lowest T-score tertile to the highest one in both sexes (OR, odd ratio (95% CI, confidence interval) of tertile 2 and 3 at 1.49 (0.8 to 2.8) and 2.46 (1.3 to 4.7), p = 0.02 in males and 1.35 (1.0 to 1.7) and 1.45 (1.1 to1.9), p < 0.01 in females). The odds remained significant even after adjustments with age, body mass index (BMI), and other risk factors associated with bone loss. Among the components of MetS, only central obesity showed a significant positive association with T-score. The study suggests a significant positive association of T-score (spine) with full MetS irrespective of sex, and among the components of MetS this positive association was seen specifically with central obesity. MDPI 2019-06-21 /pmc/articles/PMC6627685/ /pubmed/31234393 http://dx.doi.org/10.3390/nu11061405 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wani, Kaiser
Yakout, Sobhy M.
Ansari, Mohammed Ghouse Ahmed
Sabico, Shaun
Hussain, Syed Danish
Alokail, Majed S.
Sheshah, Eman
Aljohani, Naji J.
Al-Saleh, Yousef
Reginster, Jean-Yves
Al-Daghri, Nasser M.
Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title_full Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title_fullStr Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title_full_unstemmed Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title_short Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
title_sort metabolic syndrome in arab adults with low bone mineral density
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627685/
https://www.ncbi.nlm.nih.gov/pubmed/31234393
http://dx.doi.org/10.3390/nu11061405
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