Cargando…

Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells

MSC-derived exosomes display, among others, an efficient biocompatibility and a reduced intrinsic immunogenicity, representing a valuable vehicle for drug delivery in a tumor-therapeutic approach. Following treatment of several human mesenchymal stroma/stem-like cell (MSC) populations with sub-letha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melzer, Catharina, Rehn, Vanessa, Yang, Yuanyuan, Bähre, Heike, von der Ohe, Juliane, Hass, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627807/ https://www.ncbi.nlm.nih.gov/pubmed/31181850 http://dx.doi.org/10.3390/cancers11060798

Ejemplares similares

Anti-Tumor Effects of Exosomes Derived from Drug-Incubated Permanently Growing Human MSC
por: Melzer, Catharina, et al.
Publicado: (2020)

Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC)
por: Melzer, Catharina, et al.
Publicado: (2018)

Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
por: Melzer, Catharina, et al.
Publicado: (2020)

Spontaneous Fusion of MSC with Breast Cancer Cells Can Generate Tumor Dormancy
por: Melzer, Catharina, et al.
Publicado: (2021)

MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells
por: Melzer, Catharina, et al.
Publicado: (2018)

Interaction of MSC with tumor cells
por: Melzer, Catharina, et al.
Publicado: (2016)

Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line
por: Melzer, Catharina, et al.
Publicado: (2020)

Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC)
por: Melzer, Catharina, et al.
Publicado: (2019)

MSC-Derived Extracellular Vesicles in Tumors and Therapy
por: Luo, Tianjiao, et al.
Publicado: (2021)

Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells
por: Liao, Chieh Ming, et al.
Publicado: (2021)

Conditioned umbilical cord tissue provides a natural three-dimensional storage compartment as in vitro stem cell niche for human mesenchymal stroma/stem cells
por: Yang, Yuanyuan, et al.
Publicado: (2016)

Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation
por: Hass, Ralf, et al.
Publicado: (2019)

Involvement of Actin Cytoskeletal Components in Breast Cancer Cell Fusion with Human Mesenchymal Stroma/Stem-Like Cells
por: Melzer, Catharina, et al.
Publicado: (2019)

In Vivo Cell Fusion between Mesenchymal Stroma/Stem-Like Cells and Breast Cancer Cells
por: Melzer, Catharina, et al.
Publicado: (2019)

Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites
por: Melzer, Catharina, et al.
Publicado: (2017)

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b
por: Melzer, Catharina, et al.
Publicado: (2017)

Role of MSC in the Tumor Microenvironment
por: Hass, Ralf
Publicado: (2020)

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
por: Melzer, Catharina, et al.
Publicado: (2017)

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma
por: Melzer, Catharina, et al.
Publicado: (2017)

Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
por: Stapel, Britta, et al.
Publicado: (2021)

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC
por: Hass, Ralf, et al.
Publicado: (2011)

The microRNA regulatory landscape of MSC-derived exosomes: a systems view
por: Ferguson, Scott W., et al.
Publicado: (2018)

Editorial: MSC-derived exosomes in tissue regeneration
por: Chen, Xin-Ming, et al.
Publicado: (2023)

The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes
por: Hass, Ralf, et al.
Publicado: (2020)

Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness
por: Hass, Ralf, et al.
Publicado: (2020)

Cancer Cell Fusion and Post-Hybrid Selection Process (PHSP)
por: Hass, Ralf, et al.
Publicado: (2021)

Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo
por: Hass, Ralf, et al.
Publicado: (2021)

Characteristics of culture-condition stimulated exosomes or their loaded hydrogels in comparison with other extracellular vesicles or MSC lysates
por: Luo, Yu, et al.
Publicado: (2022)

Dual Role of MSC-Derived Exosomes in Tumor Development
por: Zhao, Rou, et al.
Publicado: (2020)

Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes
por: Kore, Rajshekhar A., et al.
Publicado: (2019)

Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes
por: Loh, Jia Tong, et al.
Publicado: (2022)

Corrigendum: Editorial: MSC-derived exosomes in tissue regeneration
por: Chen, Xin-Ming, et al.
Publicado: (2023)

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
por: Lai, Ruenn Chai, et al.
Publicado: (2012)

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease
por: Reza-Zaldivar, Edwin E., et al.
Publicado: (2018)

The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation
por: Zheng, Qingyuan, et al.
Publicado: (2021)

Bioengineered MSC-derived exosomes in skin wound repair and regeneration
por: Zhao, Hanxing, et al.
Publicado: (2023)

MSC.sTRAIL Has Better Efficacy than MSC.FL-TRAIL and in Combination with AKTi Blocks Pro-Metastatic Cytokine Production in Prostate Cancer Cells
por: Mohr, Andrea, et al.
Publicado: (2019)

RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression
por: Melzer, Catharina, et al.
Publicado: (2019)

MSC exosome works through a protein-based mechanism of action
por: Toh, Wei Seong, et al.
Publicado: (2018)

Defined MSC exosome with high yield and purity to improve regenerative activity
por: Kim, Jun Yong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4unq8f9qoo8ge7sjfglaqa35k0