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Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI

Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI. A nomogram was developed based on a Cox...

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Autores principales: Mariani, Pascale, Dureau, Sylvain, Savignoni, Alexia, Rouic, Livia Lumbroso-Le, Levy-Gabriel, Christine, Piperno-Neumann, Sophie, Rodrigues, Manuel J., Desjardins, Laurence, Cassoux, Nathalie, Servois, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627813/
https://www.ncbi.nlm.nih.gov/pubmed/31234340
http://dx.doi.org/10.3390/cancers11060863
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author Mariani, Pascale
Dureau, Sylvain
Savignoni, Alexia
Rouic, Livia Lumbroso-Le
Levy-Gabriel, Christine
Piperno-Neumann, Sophie
Rodrigues, Manuel J.
Desjardins, Laurence
Cassoux, Nathalie
Servois, Vincent
author_facet Mariani, Pascale
Dureau, Sylvain
Savignoni, Alexia
Rouic, Livia Lumbroso-Le
Levy-Gabriel, Christine
Piperno-Neumann, Sophie
Rodrigues, Manuel J.
Desjardins, Laurence
Cassoux, Nathalie
Servois, Vincent
author_sort Mariani, Pascale
collection PubMed
description Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI. A nomogram was developed based on a Cox model. The predictive performance of the model was assessed according to the C-statistic, Kaplan–Meier curve, and calibration plots. The median follow-up was 49.2 months (range, 0.6–70.9). The survival rates at 6, 12, and 24 months were 0.88 (0.95 CI [0.84–0.93]), 0.68 (0.95 CI [0.62–0.75]), and 0.26 (0.95 CI [0.21–0.33]), respectively. The four factors selected for the nomogram with a worse prognosis were: A disease-free interval between the UM and LMUM groups of less than 6 months (HR = 3.39; 0.95 CI [1.90–6.05]), more than 10 LMUM (HR = 3.95; 0.95 CI [1.97–4.43]), a maximum LMUM of more than 1200 mm2 (HR = 2.47; 0.95 CI [1.53–3.98]), and a lactate dehydrogenase (LDH) value greater than 1.5 (HR = 3.72; 0.95 CI [2.30–6.00]). The model achieved relatively good discrimination and calibration (C-statistic 0.71). This nomogram could be useful for decision-making and risk stratification for therapeutic options.
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spelling pubmed-66278132019-07-23 Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI Mariani, Pascale Dureau, Sylvain Savignoni, Alexia Rouic, Livia Lumbroso-Le Levy-Gabriel, Christine Piperno-Neumann, Sophie Rodrigues, Manuel J. Desjardins, Laurence Cassoux, Nathalie Servois, Vincent Cancers (Basel) Article Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI. A nomogram was developed based on a Cox model. The predictive performance of the model was assessed according to the C-statistic, Kaplan–Meier curve, and calibration plots. The median follow-up was 49.2 months (range, 0.6–70.9). The survival rates at 6, 12, and 24 months were 0.88 (0.95 CI [0.84–0.93]), 0.68 (0.95 CI [0.62–0.75]), and 0.26 (0.95 CI [0.21–0.33]), respectively. The four factors selected for the nomogram with a worse prognosis were: A disease-free interval between the UM and LMUM groups of less than 6 months (HR = 3.39; 0.95 CI [1.90–6.05]), more than 10 LMUM (HR = 3.95; 0.95 CI [1.97–4.43]), a maximum LMUM of more than 1200 mm2 (HR = 2.47; 0.95 CI [1.53–3.98]), and a lactate dehydrogenase (LDH) value greater than 1.5 (HR = 3.72; 0.95 CI [2.30–6.00]). The model achieved relatively good discrimination and calibration (C-statistic 0.71). This nomogram could be useful for decision-making and risk stratification for therapeutic options. MDPI 2019-06-21 /pmc/articles/PMC6627813/ /pubmed/31234340 http://dx.doi.org/10.3390/cancers11060863 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mariani, Pascale
Dureau, Sylvain
Savignoni, Alexia
Rouic, Livia Lumbroso-Le
Levy-Gabriel, Christine
Piperno-Neumann, Sophie
Rodrigues, Manuel J.
Desjardins, Laurence
Cassoux, Nathalie
Servois, Vincent
Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title_full Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title_fullStr Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title_full_unstemmed Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title_short Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
title_sort development of a prognostic nomogram for liver metastasis of uveal melanoma patients selected by liver mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627813/
https://www.ncbi.nlm.nih.gov/pubmed/31234340
http://dx.doi.org/10.3390/cancers11060863
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