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Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs

Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (M...

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Autores principales: Tandon, Dhriti, Ressler, Kyra, Petticord, Daniel, Papa, Andrea, Jiranek, Juliana, Wilkinson, Riley, Kartzinel, Rebecca Y., Ostrander, Elaine A., Burney, Nathaniel, Borden, Carol, Udell, Monique A. R., VonHoldt, Bridgett M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627829/
https://www.ncbi.nlm.nih.gov/pubmed/31181852
http://dx.doi.org/10.3390/genes10060439
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author Tandon, Dhriti
Ressler, Kyra
Petticord, Daniel
Papa, Andrea
Jiranek, Juliana
Wilkinson, Riley
Kartzinel, Rebecca Y.
Ostrander, Elaine A.
Burney, Nathaniel
Borden, Carol
Udell, Monique A. R.
VonHoldt, Bridgett M.
author_facet Tandon, Dhriti
Ressler, Kyra
Petticord, Daniel
Papa, Andrea
Jiranek, Juliana
Wilkinson, Riley
Kartzinel, Rebecca Y.
Ostrander, Elaine A.
Burney, Nathaniel
Borden, Carol
Udell, Monique A. R.
VonHoldt, Bridgett M.
author_sort Tandon, Dhriti
collection PubMed
description Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability. Using our dataset of 837 dogs, 228 of which had paired survey-based behavioral data, we discovered that one of the insertions in WBSCR17 is the most important predictor of dog sociable behaviors related to human proximity, measured by the Canine Behavioral Assessment Research Questionnaire (C-BARQ©). We found a positive correlation between insertions at Cfa6.6 and dog separation distress in the form of restlessness when about to be left alone by the owner. Lastly, assistance dogs showed significant heterozygosity deficiency at locus Cfa6.6 and higher frequency of insertions at Cfa6.6 and Cfa6.7. We suggest that training programs could utilize this genetic survey to screen for MEIs at WBSCR17 to identify dogs with sociable traits compatible with successful assistance dog performance.
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spelling pubmed-66278292019-07-23 Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs Tandon, Dhriti Ressler, Kyra Petticord, Daniel Papa, Andrea Jiranek, Juliana Wilkinson, Riley Kartzinel, Rebecca Y. Ostrander, Elaine A. Burney, Nathaniel Borden, Carol Udell, Monique A. R. VonHoldt, Bridgett M. Genes (Basel) Article Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability. Using our dataset of 837 dogs, 228 of which had paired survey-based behavioral data, we discovered that one of the insertions in WBSCR17 is the most important predictor of dog sociable behaviors related to human proximity, measured by the Canine Behavioral Assessment Research Questionnaire (C-BARQ©). We found a positive correlation between insertions at Cfa6.6 and dog separation distress in the form of restlessness when about to be left alone by the owner. Lastly, assistance dogs showed significant heterozygosity deficiency at locus Cfa6.6 and higher frequency of insertions at Cfa6.6 and Cfa6.7. We suggest that training programs could utilize this genetic survey to screen for MEIs at WBSCR17 to identify dogs with sociable traits compatible with successful assistance dog performance. MDPI 2019-06-09 /pmc/articles/PMC6627829/ /pubmed/31181852 http://dx.doi.org/10.3390/genes10060439 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tandon, Dhriti
Ressler, Kyra
Petticord, Daniel
Papa, Andrea
Jiranek, Juliana
Wilkinson, Riley
Kartzinel, Rebecca Y.
Ostrander, Elaine A.
Burney, Nathaniel
Borden, Carol
Udell, Monique A. R.
VonHoldt, Bridgett M.
Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title_full Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title_fullStr Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title_full_unstemmed Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title_short Homozygosity for Mobile Element Insertions Associated with WBSCR17 Could Predict Success in Assistance Dog Training Programs
title_sort homozygosity for mobile element insertions associated with wbscr17 could predict success in assistance dog training programs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627829/
https://www.ncbi.nlm.nih.gov/pubmed/31181852
http://dx.doi.org/10.3390/genes10060439
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