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Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography

Technetium (Tc)-99m-methoxyisobutylisonitrile (MIBI) single photon-emission computed tomography/computed tomography (SPECT/CT) is now being used increasingly for preoperative localization of parathyroid adenomas. Tc-99m-MIBI scintigraphy in a 52-year-old man with a diagnosis of primary hyperparathyr...

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Autores principales: Lee, Ji Young, Song, Hee-Sung, Choi, Jae Hyuck, Hyun, Chang Lim, Lee, Sang Ah, Choi, Joon-Hyouk, Lee, Seokjae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627855/
https://www.ncbi.nlm.nih.gov/pubmed/31159406
http://dx.doi.org/10.3390/diagnostics9020057
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author Lee, Ji Young
Song, Hee-Sung
Choi, Jae Hyuck
Hyun, Chang Lim
Lee, Sang Ah
Choi, Joon-Hyouk
Lee, Seokjae
author_facet Lee, Ji Young
Song, Hee-Sung
Choi, Jae Hyuck
Hyun, Chang Lim
Lee, Sang Ah
Choi, Joon-Hyouk
Lee, Seokjae
author_sort Lee, Ji Young
collection PubMed
description Technetium (Tc)-99m-methoxyisobutylisonitrile (MIBI) single photon-emission computed tomography/computed tomography (SPECT/CT) is now being used increasingly for preoperative localization of parathyroid adenomas. Tc-99m-MIBI scintigraphy in a 52-year-old man with a diagnosis of primary hyperparathyroidism revealed two focal areas with retention of radioactivity in the left lobe of the thyroid gland on the delayed phase of MIBI SPECT/CT but no significant focal radioactive uptake on MIBI planar images. The patient subsequently underwent left partial parathyroidectomy. Histological analysis identified one lesion to be thyroid hyperplasia and the other to be parathyroid adenoma. This case demonstrates the value of MIBI SPECT/CT for localization of a parathyroid lesion when compared with planar images and that false-positive findings can lead to misdiagnosis in a patient with coexisting thyroid disease. An appropriate diagnostic work-up that includes Tc-99m MIBI SPECT/CT in addition to ultrasonography is helpful for an accurate diagnosis in patients with concomitant thyroid disease.
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spelling pubmed-66278552019-07-23 Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography Lee, Ji Young Song, Hee-Sung Choi, Jae Hyuck Hyun, Chang Lim Lee, Sang Ah Choi, Joon-Hyouk Lee, Seokjae Diagnostics (Basel) Case Report Technetium (Tc)-99m-methoxyisobutylisonitrile (MIBI) single photon-emission computed tomography/computed tomography (SPECT/CT) is now being used increasingly for preoperative localization of parathyroid adenomas. Tc-99m-MIBI scintigraphy in a 52-year-old man with a diagnosis of primary hyperparathyroidism revealed two focal areas with retention of radioactivity in the left lobe of the thyroid gland on the delayed phase of MIBI SPECT/CT but no significant focal radioactive uptake on MIBI planar images. The patient subsequently underwent left partial parathyroidectomy. Histological analysis identified one lesion to be thyroid hyperplasia and the other to be parathyroid adenoma. This case demonstrates the value of MIBI SPECT/CT for localization of a parathyroid lesion when compared with planar images and that false-positive findings can lead to misdiagnosis in a patient with coexisting thyroid disease. An appropriate diagnostic work-up that includes Tc-99m MIBI SPECT/CT in addition to ultrasonography is helpful for an accurate diagnosis in patients with concomitant thyroid disease. MDPI 2019-06-01 /pmc/articles/PMC6627855/ /pubmed/31159406 http://dx.doi.org/10.3390/diagnostics9020057 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Lee, Ji Young
Song, Hee-Sung
Choi, Jae Hyuck
Hyun, Chang Lim
Lee, Sang Ah
Choi, Joon-Hyouk
Lee, Seokjae
Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title_full Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title_fullStr Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title_full_unstemmed Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title_short Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography/Computed Tomography
title_sort detecting synchronous parathyroid adenoma and false-positive findings on technetium-99m mibi single photon-emission computed tomography/computed tomography
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627855/
https://www.ncbi.nlm.nih.gov/pubmed/31159406
http://dx.doi.org/10.3390/diagnostics9020057
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