Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802

Five new anthraquinone derivatives, auxarthrols D–H (1–5), along with two known analogues (6–7), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism...

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Detalles Bibliográficos
Autores principales: Ge, Xueping, Sun, Chunxiao, Feng, Yanyan, Wang, Lingzhi, Peng, Jixing, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai, Zhang, Guojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627905/
https://www.ncbi.nlm.nih.gov/pubmed/31167439
http://dx.doi.org/10.3390/md17060334
Descripción
Sumario:Five new anthraquinone derivatives, auxarthrols D–H (1–5), along with two known analogues (6–7), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound 4 represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound 6, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds 1 and 3 showed cytotoxic activities with IC(50) values from 4.5 μM to 22.9 μM, while compounds 1, 3–4, and 6–7 showed promising antibacterial activities with MIC values from 12.5 μM to 200 μM. In addition, compound 7 was discovered to display potential antitubercular activity for the first time.

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