Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their gene...

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Detalles Bibliográficos
Autores principales: van der Kooij, Monique K., Speetjens, Frank M., van der Burg, Sjoerd H., Kapiteijn, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627906/
https://www.ncbi.nlm.nih.gov/pubmed/31248118
http://dx.doi.org/10.3390/cancers11060845
Descripción
Sumario:Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy.

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