Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their gene...

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Autores principales: van der Kooij, Monique K., Speetjens, Frank M., van der Burg, Sjoerd H., Kapiteijn, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627906/
https://www.ncbi.nlm.nih.gov/pubmed/31248118
http://dx.doi.org/10.3390/cancers11060845
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author van der Kooij, Monique K.
Speetjens, Frank M.
van der Burg, Sjoerd H.
Kapiteijn, Ellen
author_facet van der Kooij, Monique K.
Speetjens, Frank M.
van der Burg, Sjoerd H.
Kapiteijn, Ellen
author_sort van der Kooij, Monique K.
collection PubMed
description Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy.
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spelling pubmed-66279062019-07-23 Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types van der Kooij, Monique K. Speetjens, Frank M. van der Burg, Sjoerd H. Kapiteijn, Ellen Cancers (Basel) Review Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy. MDPI 2019-06-19 /pmc/articles/PMC6627906/ /pubmed/31248118 http://dx.doi.org/10.3390/cancers11060845 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van der Kooij, Monique K.
Speetjens, Frank M.
van der Burg, Sjoerd H.
Kapiteijn, Ellen
Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title_full Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title_fullStr Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title_full_unstemmed Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title_short Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
title_sort uveal versus cutaneous melanoma; same origin, very distinct tumor types
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627906/
https://www.ncbi.nlm.nih.gov/pubmed/31248118
http://dx.doi.org/10.3390/cancers11060845
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