Cargando…

Next-Generation Sequencing in Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Coccaro, Nicoletta, Anelli, Luisa, Zagaria, Antonella, Specchia, Giorgina, Albano, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627957/
https://www.ncbi.nlm.nih.gov/pubmed/31208040
http://dx.doi.org/10.3390/ijms20122929
_version_ 1783434854730301440
author Coccaro, Nicoletta
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Albano, Francesco
author_facet Coccaro, Nicoletta
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Albano, Francesco
author_sort Coccaro, Nicoletta
collection PubMed
description Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (NGS) have led to the recent discovery of several novel molecular entities and to a deeper understanding of the existing ones. The purpose of our review is to report the most recent discoveries obtained by NGS studies for ALL diagnosis, risk stratification, and treatment planning. We also report the first efforts at NGS use for minimal residual disease (MRD) assessment, and early studies on the application of third generation sequencing in cancer research. Lastly, we consider the need for the integration of NGS analyses in clinical practice for genomic patients profiling from the personalized medicine perspective.
format Online
Article
Text
id pubmed-6627957
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66279572019-07-23 Next-Generation Sequencing in Acute Lymphoblastic Leukemia Coccaro, Nicoletta Anelli, Luisa Zagaria, Antonella Specchia, Giorgina Albano, Francesco Int J Mol Sci Review Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (NGS) have led to the recent discovery of several novel molecular entities and to a deeper understanding of the existing ones. The purpose of our review is to report the most recent discoveries obtained by NGS studies for ALL diagnosis, risk stratification, and treatment planning. We also report the first efforts at NGS use for minimal residual disease (MRD) assessment, and early studies on the application of third generation sequencing in cancer research. Lastly, we consider the need for the integration of NGS analyses in clinical practice for genomic patients profiling from the personalized medicine perspective. MDPI 2019-06-15 /pmc/articles/PMC6627957/ /pubmed/31208040 http://dx.doi.org/10.3390/ijms20122929 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coccaro, Nicoletta
Anelli, Luisa
Zagaria, Antonella
Specchia, Giorgina
Albano, Francesco
Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title_full Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title_fullStr Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title_full_unstemmed Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title_short Next-Generation Sequencing in Acute Lymphoblastic Leukemia
title_sort next-generation sequencing in acute lymphoblastic leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627957/
https://www.ncbi.nlm.nih.gov/pubmed/31208040
http://dx.doi.org/10.3390/ijms20122929
work_keys_str_mv AT coccaronicoletta nextgenerationsequencinginacutelymphoblasticleukemia
AT anelliluisa nextgenerationsequencinginacutelymphoblasticleukemia
AT zagariaantonella nextgenerationsequencinginacutelymphoblasticleukemia
AT specchiagiorgina nextgenerationsequencinginacutelymphoblasticleukemia
AT albanofrancesco nextgenerationsequencinginacutelymphoblasticleukemia