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Human Papilloma Virus-Associated Cervical Cancer and Health Disparities
Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwid...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628030/ https://www.ncbi.nlm.nih.gov/pubmed/31234354 http://dx.doi.org/10.3390/cells8060622 |
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author | Olusola, Patti Banerjee, Hirendra Nath Philley, Julie V. Dasgupta, Santanu |
author_facet | Olusola, Patti Banerjee, Hirendra Nath Philley, Julie V. Dasgupta, Santanu |
author_sort | Olusola, Patti |
collection | PubMed |
description | Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwide and in the USA. However, considerable discordance in the occurrence and outcome of cervical cancer in various populations exists. Lack of adequate health insurance appears to act as a major socioeconomic burden for obtaining cervical cancer preventive screening in a timely manner, which results in disparate cervical cancer incidence. On the other hand, cervical cancer is aggressive and often detected in advanced stages, including African American and Hispanic/Latina women. In this context, our knowledge of the underlying molecular mechanism and genetic basis behind the disparate cervical cancer outcome is limited. In this review, we shed light on our current understanding and knowledge of racially disparate outcomes in cervical cancer. |
format | Online Article Text |
id | pubmed-6628030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66280302019-07-23 Human Papilloma Virus-Associated Cervical Cancer and Health Disparities Olusola, Patti Banerjee, Hirendra Nath Philley, Julie V. Dasgupta, Santanu Cells Review Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwide and in the USA. However, considerable discordance in the occurrence and outcome of cervical cancer in various populations exists. Lack of adequate health insurance appears to act as a major socioeconomic burden for obtaining cervical cancer preventive screening in a timely manner, which results in disparate cervical cancer incidence. On the other hand, cervical cancer is aggressive and often detected in advanced stages, including African American and Hispanic/Latina women. In this context, our knowledge of the underlying molecular mechanism and genetic basis behind the disparate cervical cancer outcome is limited. In this review, we shed light on our current understanding and knowledge of racially disparate outcomes in cervical cancer. MDPI 2019-06-21 /pmc/articles/PMC6628030/ /pubmed/31234354 http://dx.doi.org/10.3390/cells8060622 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Olusola, Patti Banerjee, Hirendra Nath Philley, Julie V. Dasgupta, Santanu Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title | Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title_full | Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title_fullStr | Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title_full_unstemmed | Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title_short | Human Papilloma Virus-Associated Cervical Cancer and Health Disparities |
title_sort | human papilloma virus-associated cervical cancer and health disparities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628030/ https://www.ncbi.nlm.nih.gov/pubmed/31234354 http://dx.doi.org/10.3390/cells8060622 |
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