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Food Addiction Symptoms and Amygdala Response in Fasted and Fed States
Few studies have investigated the underlying neural substrates of food addiction (FA) in humans using a recognised assessment tool. In addition, no studies have investigated subregions of the amygdala (basolateral (BLA) and central amygdala), which have been linked to reward-seeking behaviours, susc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628069/ https://www.ncbi.nlm.nih.gov/pubmed/31174338 http://dx.doi.org/10.3390/nu11061285 |
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author | Pursey, Kirrilly M. Contreras-Rodriguez, Oren Collins, Clare E. Stanwell, Peter Burrows, Tracy L. |
author_facet | Pursey, Kirrilly M. Contreras-Rodriguez, Oren Collins, Clare E. Stanwell, Peter Burrows, Tracy L. |
author_sort | Pursey, Kirrilly M. |
collection | PubMed |
description | Few studies have investigated the underlying neural substrates of food addiction (FA) in humans using a recognised assessment tool. In addition, no studies have investigated subregions of the amygdala (basolateral (BLA) and central amygdala), which have been linked to reward-seeking behaviours, susceptibility to weight gain, and promoting appetitive behaviours, in the context of FA. This pilot study aimed to explore the association between FA symptoms and activation in the BLA and central amygdala via functional magnetic resonance imaging (fMRI), in response to visual food cues in fasted and fed states. Females (n = 12) aged 18–35 years completed two fMRI scans (fasted and fed) while viewing high-calorie food images and low-calorie food images. Food addiction symptoms were assessed using the Yale Food Addiction Scale. Associations between FA symptoms and activation of the BLA and central amygdala were tested using bilateral masks and small-volume correction procedures in multiple regression models, controlling for BMI. Participants were 24.1 ± 2.6 years, with mean BMI of 27.4 ± 5.0 kg/m(2) and FA symptom score of 4.1 ± 2.2. A significant positive association was identified between FA symptoms and higher activation of the left BLA to high-calorie versus low-calorie foods in the fasted session, but not the fed session. There were no significant associations with the central amygdala in either session. This exploratory study provides pilot data to inform future studies investigating the neural mechanisms underlying FA. |
format | Online Article Text |
id | pubmed-6628069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66280692019-07-23 Food Addiction Symptoms and Amygdala Response in Fasted and Fed States Pursey, Kirrilly M. Contreras-Rodriguez, Oren Collins, Clare E. Stanwell, Peter Burrows, Tracy L. Nutrients Article Few studies have investigated the underlying neural substrates of food addiction (FA) in humans using a recognised assessment tool. In addition, no studies have investigated subregions of the amygdala (basolateral (BLA) and central amygdala), which have been linked to reward-seeking behaviours, susceptibility to weight gain, and promoting appetitive behaviours, in the context of FA. This pilot study aimed to explore the association between FA symptoms and activation in the BLA and central amygdala via functional magnetic resonance imaging (fMRI), in response to visual food cues in fasted and fed states. Females (n = 12) aged 18–35 years completed two fMRI scans (fasted and fed) while viewing high-calorie food images and low-calorie food images. Food addiction symptoms were assessed using the Yale Food Addiction Scale. Associations between FA symptoms and activation of the BLA and central amygdala were tested using bilateral masks and small-volume correction procedures in multiple regression models, controlling for BMI. Participants were 24.1 ± 2.6 years, with mean BMI of 27.4 ± 5.0 kg/m(2) and FA symptom score of 4.1 ± 2.2. A significant positive association was identified between FA symptoms and higher activation of the left BLA to high-calorie versus low-calorie foods in the fasted session, but not the fed session. There were no significant associations with the central amygdala in either session. This exploratory study provides pilot data to inform future studies investigating the neural mechanisms underlying FA. MDPI 2019-06-06 /pmc/articles/PMC6628069/ /pubmed/31174338 http://dx.doi.org/10.3390/nu11061285 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pursey, Kirrilly M. Contreras-Rodriguez, Oren Collins, Clare E. Stanwell, Peter Burrows, Tracy L. Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title | Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title_full | Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title_fullStr | Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title_full_unstemmed | Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title_short | Food Addiction Symptoms and Amygdala Response in Fasted and Fed States |
title_sort | food addiction symptoms and amygdala response in fasted and fed states |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628069/ https://www.ncbi.nlm.nih.gov/pubmed/31174338 http://dx.doi.org/10.3390/nu11061285 |
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