Cargando…
The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the different compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the pres...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628074/ https://www.ncbi.nlm.nih.gov/pubmed/31226852 http://dx.doi.org/10.3390/ijms20123022 |
_version_ | 1783434881295974400 |
---|---|
author | Maiuolo, Jessica Gliozzi, Micaela Musolino, Vincenzo Carresi, Cristina Nucera, Saverio Macrì, Roberta Scicchitano, Miriam Bosco, Francesca Scarano, Federica Ruga, Stefano Zito, Maria Caterina Oppedisano, Francesca Mollace, Rocco Paone, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo |
author_facet | Maiuolo, Jessica Gliozzi, Micaela Musolino, Vincenzo Carresi, Cristina Nucera, Saverio Macrì, Roberta Scicchitano, Miriam Bosco, Francesca Scarano, Federica Ruga, Stefano Zito, Maria Caterina Oppedisano, Francesca Mollace, Rocco Paone, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo |
author_sort | Maiuolo, Jessica |
collection | PubMed |
description | The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the different compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve. |
format | Online Article Text |
id | pubmed-6628074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66280742019-07-23 The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications Maiuolo, Jessica Gliozzi, Micaela Musolino, Vincenzo Carresi, Cristina Nucera, Saverio Macrì, Roberta Scicchitano, Miriam Bosco, Francesca Scarano, Federica Ruga, Stefano Zito, Maria Caterina Oppedisano, Francesca Mollace, Rocco Paone, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo Int J Mol Sci Review The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the different compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve. MDPI 2019-06-20 /pmc/articles/PMC6628074/ /pubmed/31226852 http://dx.doi.org/10.3390/ijms20123022 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maiuolo, Jessica Gliozzi, Micaela Musolino, Vincenzo Carresi, Cristina Nucera, Saverio Macrì, Roberta Scicchitano, Miriam Bosco, Francesca Scarano, Federica Ruga, Stefano Zito, Maria Caterina Oppedisano, Francesca Mollace, Rocco Paone, Sara Palma, Ernesto Muscoli, Carolina Mollace, Vincenzo The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title | The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title_full | The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title_fullStr | The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title_full_unstemmed | The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title_short | The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications |
title_sort | role of endothelial dysfunction in peripheral blood nerve barrier: molecular mechanisms and pathophysiological implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628074/ https://www.ncbi.nlm.nih.gov/pubmed/31226852 http://dx.doi.org/10.3390/ijms20123022 |
work_keys_str_mv | AT maiuolojessica theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT gliozzimicaela theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT musolinovincenzo theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT carresicristina theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT nucerasaverio theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT macriroberta theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT scicchitanomiriam theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT boscofrancesca theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT scaranofederica theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT rugastefano theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT zitomariacaterina theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT oppedisanofrancesca theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT mollacerocco theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT paonesara theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT palmaernesto theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT muscolicarolina theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT mollacevincenzo theroleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT maiuolojessica roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT gliozzimicaela roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT musolinovincenzo roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT carresicristina roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT nucerasaverio roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT macriroberta roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT scicchitanomiriam roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT boscofrancesca roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT scaranofederica roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT rugastefano roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT zitomariacaterina roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT oppedisanofrancesca roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT mollacerocco roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT paonesara roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT palmaernesto roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT muscolicarolina roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications AT mollacevincenzo roleofendothelialdysfunctioninperipheralbloodnervebarriermolecularmechanismsandpathophysiologicalimplications |