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The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome

Nutrition in the postnatal period is associated with metabolic programming. One of the presumed underlying mechanisms involves epigenetic modifications (e.g., DNA methylation). Breastfeeding has an unknown impact on DNA methylation at a young age. Within the Maternal Nutrition and Offspring’s Epigen...

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Autores principales: Pauwels, Sara, Symons, Lin, Vanautgaerden, Eva-Lynn, Ghosh, Manosij, Duca, Radu Corneliu, Bekaert, Bram, Freson, Kathleen, Huybrechts, Inge, Langie, Sabine A. S., Koppen, Gudrun, Devlieger, Roland, Godderis, Lode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628078/
https://www.ncbi.nlm.nih.gov/pubmed/31234503
http://dx.doi.org/10.3390/nu11061408
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author Pauwels, Sara
Symons, Lin
Vanautgaerden, Eva-Lynn
Ghosh, Manosij
Duca, Radu Corneliu
Bekaert, Bram
Freson, Kathleen
Huybrechts, Inge
Langie, Sabine A. S.
Koppen, Gudrun
Devlieger, Roland
Godderis, Lode
author_facet Pauwels, Sara
Symons, Lin
Vanautgaerden, Eva-Lynn
Ghosh, Manosij
Duca, Radu Corneliu
Bekaert, Bram
Freson, Kathleen
Huybrechts, Inge
Langie, Sabine A. S.
Koppen, Gudrun
Devlieger, Roland
Godderis, Lode
author_sort Pauwels, Sara
collection PubMed
description Nutrition in the postnatal period is associated with metabolic programming. One of the presumed underlying mechanisms involves epigenetic modifications (e.g., DNA methylation). Breastfeeding has an unknown impact on DNA methylation at a young age. Within the Maternal Nutrition and Offspring’s Epigenome (MANOE) study, we assessed the effect of breastfeeding duration on infant growth and buccal methylation in obesity-related genes (n = 101). A significant difference was found between infant growth and buccal RXRA and LEP methylation at 12 months of breastfeeding. For RXRA CpG2 methylation, a positive association was found with duration of breastfeeding (slope = 0.217; 95% confidence interval (CI) 1.03, 0.330; p < 0.001). For RXRA CpG3 and CpG, mean methylation levels were significantly lower when children were breastfed for 4–6 months compared to non-breastfed children (only CpG3), and those breastfed for 7–9 months, 10–12 months, or 1–3 months. On the other hand, higher LEP CpG3 methylation was observed when mothers breastfed 7–9 months (6.1%) as compared to breastfeeding for 1–3 months (4.3%; p = 0.007) and 10–12 months (4.6%; p = 0.04). In addition, we observed that infant weight was significantly lower when children were breastfed for 10–12 months. Breastfeeding duration was associated with epigenetic variations in RXRA and LEP at 12 months and with infant biometry/growth. Our results support the hypothesis that breastfeeding could induce epigenetic changes in infants.
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spelling pubmed-66280782019-07-23 The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome Pauwels, Sara Symons, Lin Vanautgaerden, Eva-Lynn Ghosh, Manosij Duca, Radu Corneliu Bekaert, Bram Freson, Kathleen Huybrechts, Inge Langie, Sabine A. S. Koppen, Gudrun Devlieger, Roland Godderis, Lode Nutrients Article Nutrition in the postnatal period is associated with metabolic programming. One of the presumed underlying mechanisms involves epigenetic modifications (e.g., DNA methylation). Breastfeeding has an unknown impact on DNA methylation at a young age. Within the Maternal Nutrition and Offspring’s Epigenome (MANOE) study, we assessed the effect of breastfeeding duration on infant growth and buccal methylation in obesity-related genes (n = 101). A significant difference was found between infant growth and buccal RXRA and LEP methylation at 12 months of breastfeeding. For RXRA CpG2 methylation, a positive association was found with duration of breastfeeding (slope = 0.217; 95% confidence interval (CI) 1.03, 0.330; p < 0.001). For RXRA CpG3 and CpG, mean methylation levels were significantly lower when children were breastfed for 4–6 months compared to non-breastfed children (only CpG3), and those breastfed for 7–9 months, 10–12 months, or 1–3 months. On the other hand, higher LEP CpG3 methylation was observed when mothers breastfed 7–9 months (6.1%) as compared to breastfeeding for 1–3 months (4.3%; p = 0.007) and 10–12 months (4.6%; p = 0.04). In addition, we observed that infant weight was significantly lower when children were breastfed for 10–12 months. Breastfeeding duration was associated with epigenetic variations in RXRA and LEP at 12 months and with infant biometry/growth. Our results support the hypothesis that breastfeeding could induce epigenetic changes in infants. MDPI 2019-06-22 /pmc/articles/PMC6628078/ /pubmed/31234503 http://dx.doi.org/10.3390/nu11061408 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pauwels, Sara
Symons, Lin
Vanautgaerden, Eva-Lynn
Ghosh, Manosij
Duca, Radu Corneliu
Bekaert, Bram
Freson, Kathleen
Huybrechts, Inge
Langie, Sabine A. S.
Koppen, Gudrun
Devlieger, Roland
Godderis, Lode
The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title_full The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title_fullStr The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title_full_unstemmed The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title_short The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome
title_sort influence of the duration of breastfeeding on the infant’s metabolic epigenome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628078/
https://www.ncbi.nlm.nih.gov/pubmed/31234503
http://dx.doi.org/10.3390/nu11061408
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