Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

Mammalian mitochondria contain four topoisomerases encoded in the nuclear genome: TOP1MT, TOP2α, TOP2β, and TOP3α. They also contain the two known tyrosyl-DNA phosphodiesterases (TDPs): TDP1 and TDP2, including a specific TDP2(S) isoform. Both TDP1 and TDP2 excise abortive topoisomerase cleavage com...

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Detalles Bibliográficos
Autores principales: Huang, Shar-yin Naomi, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628236/
https://www.ncbi.nlm.nih.gov/pubmed/31226795
http://dx.doi.org/10.3390/ijms20123015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628236/
https://www.ncbi.nlm.nih.gov/pubmed/31226795
http://dx.doi.org/10.3390/ijms20123015

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