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Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or met...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628316/ https://www.ncbi.nlm.nih.gov/pubmed/31226786 http://dx.doi.org/10.3390/cancers11060856 |
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author | Anand, Kartik Roszik, Jason Gombos, Dan Upshaw, Joshua Sarli, Vanessa Meas, Salyna Lucci, Anthony Hall, Carolyn Patel, Sapna |
author_facet | Anand, Kartik Roszik, Jason Gombos, Dan Upshaw, Joshua Sarli, Vanessa Meas, Salyna Lucci, Anthony Hall, Carolyn Patel, Sapna |
author_sort | Anand, Kartik |
collection | PubMed |
description | Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (p < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes. |
format | Online Article Text |
id | pubmed-6628316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66283162019-07-23 Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma Anand, Kartik Roszik, Jason Gombos, Dan Upshaw, Joshua Sarli, Vanessa Meas, Salyna Lucci, Anthony Hall, Carolyn Patel, Sapna Cancers (Basel) Article Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (p < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes. MDPI 2019-06-20 /pmc/articles/PMC6628316/ /pubmed/31226786 http://dx.doi.org/10.3390/cancers11060856 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Anand, Kartik Roszik, Jason Gombos, Dan Upshaw, Joshua Sarli, Vanessa Meas, Salyna Lucci, Anthony Hall, Carolyn Patel, Sapna Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title | Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title_full | Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title_fullStr | Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title_full_unstemmed | Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title_short | Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma |
title_sort | pilot study of circulating tumor cells in early-stage and metastatic uveal melanoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628316/ https://www.ncbi.nlm.nih.gov/pubmed/31226786 http://dx.doi.org/10.3390/cancers11060856 |
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