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Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite

Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which...

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Autores principales: Moon, Hyunwoo, Choy, Seunghwan, Park, Yeonju, Jung, Young Mee, Koo, Jun Mo, Hwang, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628339/
https://www.ncbi.nlm.nih.gov/pubmed/31151236
http://dx.doi.org/10.3390/md17060318
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author Moon, Hyunwoo
Choy, Seunghwan
Park, Yeonju
Jung, Young Mee
Koo, Jun Mo
Hwang, Dong Soo
author_facet Moon, Hyunwoo
Choy, Seunghwan
Park, Yeonju
Jung, Young Mee
Koo, Jun Mo
Hwang, Dong Soo
author_sort Moon, Hyunwoo
collection PubMed
description Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, α- and β-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/α-chitin has two distinctive phases in the composite, but β-chitin composite has a relatively homogeneous phase. The β-chitin composite showed better tensile strength with ~41% and ~14% higher strength compared to collagen and α-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that β-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike α-chitin.
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spelling pubmed-66283392019-07-23 Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite Moon, Hyunwoo Choy, Seunghwan Park, Yeonju Jung, Young Mee Koo, Jun Mo Hwang, Dong Soo Mar Drugs Article Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, α- and β-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/α-chitin has two distinctive phases in the composite, but β-chitin composite has a relatively homogeneous phase. The β-chitin composite showed better tensile strength with ~41% and ~14% higher strength compared to collagen and α-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that β-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike α-chitin. MDPI 2019-05-30 /pmc/articles/PMC6628339/ /pubmed/31151236 http://dx.doi.org/10.3390/md17060318 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moon, Hyunwoo
Choy, Seunghwan
Park, Yeonju
Jung, Young Mee
Koo, Jun Mo
Hwang, Dong Soo
Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title_full Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title_fullStr Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title_full_unstemmed Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title_short Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
title_sort different molecular interaction between collagen and α- or β-chitin in mechanically improved electrospun composite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628339/
https://www.ncbi.nlm.nih.gov/pubmed/31151236
http://dx.doi.org/10.3390/md17060318
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