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Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite
Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628339/ https://www.ncbi.nlm.nih.gov/pubmed/31151236 http://dx.doi.org/10.3390/md17060318 |
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author | Moon, Hyunwoo Choy, Seunghwan Park, Yeonju Jung, Young Mee Koo, Jun Mo Hwang, Dong Soo |
author_facet | Moon, Hyunwoo Choy, Seunghwan Park, Yeonju Jung, Young Mee Koo, Jun Mo Hwang, Dong Soo |
author_sort | Moon, Hyunwoo |
collection | PubMed |
description | Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, α- and β-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/α-chitin has two distinctive phases in the composite, but β-chitin composite has a relatively homogeneous phase. The β-chitin composite showed better tensile strength with ~41% and ~14% higher strength compared to collagen and α-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that β-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike α-chitin. |
format | Online Article Text |
id | pubmed-6628339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66283392019-07-23 Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite Moon, Hyunwoo Choy, Seunghwan Park, Yeonju Jung, Young Mee Koo, Jun Mo Hwang, Dong Soo Mar Drugs Article Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, α- and β-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/α-chitin has two distinctive phases in the composite, but β-chitin composite has a relatively homogeneous phase. The β-chitin composite showed better tensile strength with ~41% and ~14% higher strength compared to collagen and α-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that β-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike α-chitin. MDPI 2019-05-30 /pmc/articles/PMC6628339/ /pubmed/31151236 http://dx.doi.org/10.3390/md17060318 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moon, Hyunwoo Choy, Seunghwan Park, Yeonju Jung, Young Mee Koo, Jun Mo Hwang, Dong Soo Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title | Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title_full | Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title_fullStr | Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title_full_unstemmed | Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title_short | Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite |
title_sort | different molecular interaction between collagen and α- or β-chitin in mechanically improved electrospun composite |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628339/ https://www.ncbi.nlm.nih.gov/pubmed/31151236 http://dx.doi.org/10.3390/md17060318 |
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