Cargando…

Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors

Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence attributed to different factors. We compared cellular intoxication by TcdB(NAP1) w...

Descripción completa

Detalles Bibliográficos
Autores principales:	López-Ureña, Diana, Orozco-Aguilar, Josué, Chaves-Madrigal, Yendry, Ramírez-Mata, Andrea, Villalobos-Jimenez, Amanda, Ost, Stefan, Quesada-Gómez, Carlos, Rodríguez, César, Papatheodorou, Panagiotis, Chaves-Olarte, Esteban
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628394/ https://www.ncbi.nlm.nih.gov/pubmed/31212980 http://dx.doi.org/10.3390/toxins11060348

Ejemplares similares

In vivo animal models confirm an increased virulence potential and pathogenicity of the NAP1/RT027/ST01 genotype within the Clostridium difficile MLST Clade 2
por: Orozco-Aguilar, Josué, et al.
Publicado: (2020)

Difference in F-Actin Depolymerization Induced by Toxin B from the Clostridium difficile Strain VPI 10463 and Toxin B from the Variant Clostridium difficile Serotype F Strain 1470
por: May, Martin, et al.
Publicado: (2013)

Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027
por: Burns, David A., et al.
Publicado: (2011)

First Report of Clostridium difficile NAP1/027 in a Mexican Hospital
por: Camacho-Ortiz, Adrián, et al.
Publicado: (2015)

Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital
por: Morfin-Otero, Rayo, et al.
Publicado: (2015)

Correction: First Report of Clostridium difficile NAP1/027 in a Mexican Hospital
por: Camacho-Ortiz, Adrián, et al.
Publicado: (2015)

Prevalence of Hypervirulent BI/NAP1/027 Clostridium difficile Strains in Cali-Colombia
por: Rosso, Fernando, et al.
Publicado: (2017)

The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview
por: Fatima, Rawish, et al.
Publicado: (2019)

Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB
por: Lanis, Jordi M., et al.
Publicado: (2013)

Risk Factors for BI/NAP1/027 Clostridioides difficile Infections and Clinical Outcomes Compared With Non-NAP1 Strains
por: Mani, Nandita S, et al.
Publicado: (2019)

The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile
por: Carter, Glen P., et al.
Publicado: (2011)

Emergence of a highly resistant Clostridium difficile strain (NAP/BI/027) in a tertiary care center in Saudi Arabia
por: Alzahrani, Nabeel, et al.
Publicado: (2013)

Emergence of Clostridium difficile Ribotype 027 in Korea
por: Kim, Heejung, et al.
Publicado: (2011)

Epidemic Clostridium difficile Ribotype 027 in Chile
por: Hernández-Rocha, Cristian, et al.
Publicado: (2012)

Clostridium difficile 027 infection in Central Italy
por: Di Bella, Stefano, et al.
Publicado: (2012)

Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico
por: Guerrero-Araya, Enzo, et al.
Publicado: (2020)

Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
por: Ramírez-Vargas, Gabriel, et al.
Publicado: (2018)

748. The Changing Epidemiology of Clostridioides difficile Infection and the NAP1/027 Strain in Two Quebec Hospitals
por: Couture, Sandrine, et al.
Publicado: (2021)

Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain
por: Morais, Maria Luana Gaudencio dos Santos, et al.
Publicado: (2022)

Clostridium difficile Ribotype 027, Toxinotype III, the Netherlands
por: Kuijper, Ed J., et al.
Publicado: (2006)

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile
por: Dong, Qiwen, et al.
Publicado: (2023)

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile
por: Dong, Qiwen, et al.
Publicado: (2023)

1120. Clostridium difficile Infection Risk Factors, Severity, and Outcomes in Patients Infected with NAP1/027 Strain in a Non-Epidemic Setting
por: Nahar, Julie
Publicado: (2018)

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB
por: Papatheodorou, Panagiotis, et al.
Publicado: (2021)

479. Trends in C. difficile Incidence, Mortality, and NAP1/027 Strain in the Population of Monroe County, New York
por: Hatwar, Trupti, et al.
Publicado: (2018)

Diverse Temperate Bacteriophage Carriage in Clostridium difficile 027 Strains
por: Nale, Janet Y., et al.
Publicado: (2012)

A search for Clostridium difficile ribotypes 027 and 078 in Brazil
por: de Almeida Monteiro, Alexandre, et al.
Publicado: (2014)

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
por: Quesada-Gómez, Carlos, et al.
Publicado: (2016)

Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAP(CR1) and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks
por: López-Ureña, Diana, et al.
Publicado: (2016)

Clindamycin-Resistant Clone of Clostridium difficile PCR Ribotype 027, Europe
por: Drudy, Denise, et al.
Publicado: (2008)

gyrA Mutations in Fluoroquinolone-resistant Clostridium difficile PCR-027
por: Drudy, Denise, et al.
Publicado: (2007)

The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027
por: Martin, Melissa J., et al.
Publicado: (2013)

An Observational Cohort Study of Clostridium difficile Ribotype 027 and Recurrent Infection
por: Rao, Krishna, et al.
Publicado: (2018)

Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence
por: Quesada-Gómez, Carlos, et al.
Publicado: (2015)

Surface Layer Protein A Variant of Clostridium difficile PCR-Ribotype 027
por: Spigaglia, Patrizia, et al.
Publicado: (2011)

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains
por: Dawson, Lisa F, et al.
Publicado: (2011)

Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread
por: Clements, Archie CA, et al.
Publicado: (2010)

Clostridium difficile Enteritis With NAP7/078 Toxigenic Strain
por: Zewude, Rahel T, et al.
Publicado: (2023)

Clinical Severity of Clostridium difficile PCR Ribotype 027: A Case-Case Study
por: Morgan, Oliver W., et al.
Publicado: (2008)

Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291
por: Buckley, Anthony M., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vnackmg1rinn9cincbckoir56v