Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin...

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Detalles Bibliográficos
Autores principales: Seiti Yamada Yoshikawa, Fabio, Feitosa de Lima, Josenilson, Notomi Sato, Maria, Álefe Leuzzi Ramos, Yasmin, Aoki, Valeria, Leao Orfali, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628437/
https://www.ncbi.nlm.nih.gov/pubmed/31195639
http://dx.doi.org/10.3390/toxins11060321
Descripción
Sumario:Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

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