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Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are m...

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Autores principales: Chaves-Moreira, Daniele, Matsubara, Fernando Hitomi, Schemczssen-Graeff, Zelinda, De Bona, Elidiana, Heidemann, Vanessa Ribeiro, Guerra-Duarte, Clara, Gremski, Luiza Helena, Chávez-Olórtegui, Carlos, Senff-Ribeiro, Andrea, Chaim, Olga Meiri, Arni, Raghuvir Krishnaswamy, Veiga, Silvio Sanches
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628458/
https://www.ncbi.nlm.nih.gov/pubmed/31248109
http://dx.doi.org/10.3390/toxins11060355
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author Chaves-Moreira, Daniele
Matsubara, Fernando Hitomi
Schemczssen-Graeff, Zelinda
De Bona, Elidiana
Heidemann, Vanessa Ribeiro
Guerra-Duarte, Clara
Gremski, Luiza Helena
Chávez-Olórtegui, Carlos
Senff-Ribeiro, Andrea
Chaim, Olga Meiri
Arni, Raghuvir Krishnaswamy
Veiga, Silvio Sanches
author_facet Chaves-Moreira, Daniele
Matsubara, Fernando Hitomi
Schemczssen-Graeff, Zelinda
De Bona, Elidiana
Heidemann, Vanessa Ribeiro
Guerra-Duarte, Clara
Gremski, Luiza Helena
Chávez-Olórtegui, Carlos
Senff-Ribeiro, Andrea
Chaim, Olga Meiri
Arni, Raghuvir Krishnaswamy
Veiga, Silvio Sanches
author_sort Chaves-Moreira, Daniele
collection PubMed
description Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action.
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spelling pubmed-66284582019-07-23 Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics Chaves-Moreira, Daniele Matsubara, Fernando Hitomi Schemczssen-Graeff, Zelinda De Bona, Elidiana Heidemann, Vanessa Ribeiro Guerra-Duarte, Clara Gremski, Luiza Helena Chávez-Olórtegui, Carlos Senff-Ribeiro, Andrea Chaim, Olga Meiri Arni, Raghuvir Krishnaswamy Veiga, Silvio Sanches Toxins (Basel) Review Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action. MDPI 2019-06-19 /pmc/articles/PMC6628458/ /pubmed/31248109 http://dx.doi.org/10.3390/toxins11060355 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chaves-Moreira, Daniele
Matsubara, Fernando Hitomi
Schemczssen-Graeff, Zelinda
De Bona, Elidiana
Heidemann, Vanessa Ribeiro
Guerra-Duarte, Clara
Gremski, Luiza Helena
Chávez-Olórtegui, Carlos
Senff-Ribeiro, Andrea
Chaim, Olga Meiri
Arni, Raghuvir Krishnaswamy
Veiga, Silvio Sanches
Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title_full Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title_fullStr Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title_full_unstemmed Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title_short Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
title_sort brown spider (loxosceles) venom toxins as potential biotools for the development of novel therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628458/
https://www.ncbi.nlm.nih.gov/pubmed/31248109
http://dx.doi.org/10.3390/toxins11060355
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