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Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are m...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628458/ https://www.ncbi.nlm.nih.gov/pubmed/31248109 http://dx.doi.org/10.3390/toxins11060355 |
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author | Chaves-Moreira, Daniele Matsubara, Fernando Hitomi Schemczssen-Graeff, Zelinda De Bona, Elidiana Heidemann, Vanessa Ribeiro Guerra-Duarte, Clara Gremski, Luiza Helena Chávez-Olórtegui, Carlos Senff-Ribeiro, Andrea Chaim, Olga Meiri Arni, Raghuvir Krishnaswamy Veiga, Silvio Sanches |
author_facet | Chaves-Moreira, Daniele Matsubara, Fernando Hitomi Schemczssen-Graeff, Zelinda De Bona, Elidiana Heidemann, Vanessa Ribeiro Guerra-Duarte, Clara Gremski, Luiza Helena Chávez-Olórtegui, Carlos Senff-Ribeiro, Andrea Chaim, Olga Meiri Arni, Raghuvir Krishnaswamy Veiga, Silvio Sanches |
author_sort | Chaves-Moreira, Daniele |
collection | PubMed |
description | Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action. |
format | Online Article Text |
id | pubmed-6628458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66284582019-07-23 Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics Chaves-Moreira, Daniele Matsubara, Fernando Hitomi Schemczssen-Graeff, Zelinda De Bona, Elidiana Heidemann, Vanessa Ribeiro Guerra-Duarte, Clara Gremski, Luiza Helena Chávez-Olórtegui, Carlos Senff-Ribeiro, Andrea Chaim, Olga Meiri Arni, Raghuvir Krishnaswamy Veiga, Silvio Sanches Toxins (Basel) Review Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action. MDPI 2019-06-19 /pmc/articles/PMC6628458/ /pubmed/31248109 http://dx.doi.org/10.3390/toxins11060355 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chaves-Moreira, Daniele Matsubara, Fernando Hitomi Schemczssen-Graeff, Zelinda De Bona, Elidiana Heidemann, Vanessa Ribeiro Guerra-Duarte, Clara Gremski, Luiza Helena Chávez-Olórtegui, Carlos Senff-Ribeiro, Andrea Chaim, Olga Meiri Arni, Raghuvir Krishnaswamy Veiga, Silvio Sanches Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title | Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title_full | Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title_fullStr | Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title_full_unstemmed | Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title_short | Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics |
title_sort | brown spider (loxosceles) venom toxins as potential biotools for the development of novel therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628458/ https://www.ncbi.nlm.nih.gov/pubmed/31248109 http://dx.doi.org/10.3390/toxins11060355 |
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