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Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study

Fatty acids (FAs) are crucial in child growth and development. In Uganda, antiretroviral therapy (ART) has drastically reduced perinatal human immunodeficiency virus (HIV) infection of infants, however, the interplay of FAs, ART, and HIV in relation to child growth is not well understood. To investi...

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Autores principales: Jain, Raghav, Ezeamama, Amara E., Sikorskii, Alla, Yakah, William, Zalwango, Sarah, Musoke, Philippa, Boivin, Michael J., Fenton, Jenifer I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628545/
https://www.ncbi.nlm.nih.gov/pubmed/31167445
http://dx.doi.org/10.3390/nu11061268
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author Jain, Raghav
Ezeamama, Amara E.
Sikorskii, Alla
Yakah, William
Zalwango, Sarah
Musoke, Philippa
Boivin, Michael J.
Fenton, Jenifer I.
author_facet Jain, Raghav
Ezeamama, Amara E.
Sikorskii, Alla
Yakah, William
Zalwango, Sarah
Musoke, Philippa
Boivin, Michael J.
Fenton, Jenifer I.
author_sort Jain, Raghav
collection PubMed
description Fatty acids (FAs) are crucial in child growth and development. In Uganda, antiretroviral therapy (ART) has drastically reduced perinatal human immunodeficiency virus (HIV) infection of infants, however, the interplay of FAs, ART, and HIV in relation to child growth is not well understood. To investigate this, serum was collected from 240 children between 6–10 years old in Uganda and analyzed for FAs using gas-chromatography mass-spectrometry. HIV status and anthropometric measurements were taken, and relationships with FAs were assessed. No significant differences in growth parameters or serum FAs were found between HIV uninfected children with and without exposure to ART. HIV positive children had significantly lower height-for-age-z-scores (HAZ) than uninfected children (p < 0.001). HIV-positive children had higher arachidonic acid than uninfected children (p = 0.003). Total omega-6 FAs were significantly associated with HAZ regardless of HIV status (p = 0.035). Mean total omega-3 FAs (2.90%) were low in this population compared to other cohorts in Africa. These results provide reference serum FA values for 6–10-year-old children in Uganda and may be used to inform lipid supplementation programs to promote child growth. Future studies should investigate the relationships between child growth trajectories in relation to HIV status and serum FAs.
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spelling pubmed-66285452019-08-05 Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study Jain, Raghav Ezeamama, Amara E. Sikorskii, Alla Yakah, William Zalwango, Sarah Musoke, Philippa Boivin, Michael J. Fenton, Jenifer I. Nutrients Article Fatty acids (FAs) are crucial in child growth and development. In Uganda, antiretroviral therapy (ART) has drastically reduced perinatal human immunodeficiency virus (HIV) infection of infants, however, the interplay of FAs, ART, and HIV in relation to child growth is not well understood. To investigate this, serum was collected from 240 children between 6–10 years old in Uganda and analyzed for FAs using gas-chromatography mass-spectrometry. HIV status and anthropometric measurements were taken, and relationships with FAs were assessed. No significant differences in growth parameters or serum FAs were found between HIV uninfected children with and without exposure to ART. HIV positive children had significantly lower height-for-age-z-scores (HAZ) than uninfected children (p < 0.001). HIV-positive children had higher arachidonic acid than uninfected children (p = 0.003). Total omega-6 FAs were significantly associated with HAZ regardless of HIV status (p = 0.035). Mean total omega-3 FAs (2.90%) were low in this population compared to other cohorts in Africa. These results provide reference serum FA values for 6–10-year-old children in Uganda and may be used to inform lipid supplementation programs to promote child growth. Future studies should investigate the relationships between child growth trajectories in relation to HIV status and serum FAs. MDPI 2019-06-04 /pmc/articles/PMC6628545/ /pubmed/31167445 http://dx.doi.org/10.3390/nu11061268 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jain, Raghav
Ezeamama, Amara E.
Sikorskii, Alla
Yakah, William
Zalwango, Sarah
Musoke, Philippa
Boivin, Michael J.
Fenton, Jenifer I.
Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title_full Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title_fullStr Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title_full_unstemmed Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title_short Serum n-6 Fatty Acids are Positively Associated with Growth in 6-to-10-Year Old Ugandan Children Regardless of HIV Status—A Cross-Sectional Study
title_sort serum n-6 fatty acids are positively associated with growth in 6-to-10-year old ugandan children regardless of hiv status—a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628545/
https://www.ncbi.nlm.nih.gov/pubmed/31167445
http://dx.doi.org/10.3390/nu11061268
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