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Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort

Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-...

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Autores principales: Banszerus, Verena L., Vetter, Valentin M., Salewsky, Bastian, König, Maximilian, Demuth, Ilja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628615/
https://www.ncbi.nlm.nih.gov/pubmed/31234328
http://dx.doi.org/10.3390/ijms20123032
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author Banszerus, Verena L.
Vetter, Valentin M.
Salewsky, Bastian
König, Maximilian
Demuth, Ilja
author_facet Banszerus, Verena L.
Vetter, Valentin M.
Salewsky, Bastian
König, Maximilian
Demuth, Ilja
author_sort Banszerus, Verena L.
collection PubMed
description Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age.
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spelling pubmed-66286152019-08-05 Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort Banszerus, Verena L. Vetter, Valentin M. Salewsky, Bastian König, Maximilian Demuth, Ilja Int J Mol Sci Article Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age. MDPI 2019-06-21 /pmc/articles/PMC6628615/ /pubmed/31234328 http://dx.doi.org/10.3390/ijms20123032 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banszerus, Verena L.
Vetter, Valentin M.
Salewsky, Bastian
König, Maximilian
Demuth, Ilja
Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title_full Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title_fullStr Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title_full_unstemmed Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title_short Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
title_sort exploring the relationship of relative telomere length and the epigenetic clock in the lipidcardio cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628615/
https://www.ncbi.nlm.nih.gov/pubmed/31234328
http://dx.doi.org/10.3390/ijms20123032
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