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Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628615/ https://www.ncbi.nlm.nih.gov/pubmed/31234328 http://dx.doi.org/10.3390/ijms20123032 |
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author | Banszerus, Verena L. Vetter, Valentin M. Salewsky, Bastian König, Maximilian Demuth, Ilja |
author_facet | Banszerus, Verena L. Vetter, Valentin M. Salewsky, Bastian König, Maximilian Demuth, Ilja |
author_sort | Banszerus, Verena L. |
collection | PubMed |
description | Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age. |
format | Online Article Text |
id | pubmed-6628615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66286152019-08-05 Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort Banszerus, Verena L. Vetter, Valentin M. Salewsky, Bastian König, Maximilian Demuth, Ilja Int J Mol Sci Article Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age. MDPI 2019-06-21 /pmc/articles/PMC6628615/ /pubmed/31234328 http://dx.doi.org/10.3390/ijms20123032 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Banszerus, Verena L. Vetter, Valentin M. Salewsky, Bastian König, Maximilian Demuth, Ilja Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title | Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title_full | Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title_fullStr | Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title_full_unstemmed | Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title_short | Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort |
title_sort | exploring the relationship of relative telomere length and the epigenetic clock in the lipidcardio cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628615/ https://www.ncbi.nlm.nih.gov/pubmed/31234328 http://dx.doi.org/10.3390/ijms20123032 |
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