A cell topography-based mechanism for ligand discrimination by the T cell receptor

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In res...

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Detalles Bibliográficos
Autores principales: Fernandes, Ricardo A., Ganzinger, Kristina A., Tzou, Justin C., Jönsson, Peter, Lee, Steven F., Palayret, Matthieu, Santos, Ana Mafalda, Carr, Alexander R., Ponjavic, Aleks, Chang, Veronica T., Macleod, Charlotte, Lagerholm, B. Christoffer, Lindsay, Alan E., Dushek, Omer, Tilevik, Andreas, Davis, Simon J., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628812/
https://www.ncbi.nlm.nih.gov/pubmed/31221762
http://dx.doi.org/10.1073/pnas.1817255116

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