Cargando…

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass

Cellular senescence is an important mechanism of autonomous tumor suppression, while its consequence such as the senescence-associated secretory phenotype (SASP) may drive tumorigenesis and age-related diseases. Therefore, controlling the cell fate optimally when encountering senescence stress is he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xuehui, Wei, Lei, Dong, Qiongye, Liu, Liyang, Zhang, Michael Q., Xie, Zhen, Wang, Xiaowo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628988/ https://www.ncbi.nlm.nih.gov/pubmed/31219803 http://dx.doi.org/10.18632/aging.102034

Ejemplares similares

Regulatory RNA binding proteins contribute to the transcriptome-wide splicing alterations in human cellular senescence
por: Dong, Qiongye, et al.
Publicado: (2018)

The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence
por: Zhang, Xianglin, et al.
Publicado: (2021)

Genome-scale CRISPR screening for modifiers of cellular LDL uptake
por: Emmer, Brian T., et al.
Publicado: (2021)

Large-Scale CRISPR Screen of LDLR Pathogenic Variants
por: Li, Mengjing, et al.
Publicado: (2023)

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification
por: Chen, Wenhao, et al.
Publicado: (2022)

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
por: Li, Wei, et al.
Publicado: (2014)

CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation
por: Liu, Honglei, et al.
Publicado: (2015)

Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
por: Neggers, Jasper Edgar, et al.
Publicado: (2018)

Large scale microfluidic CRISPR screening for increased amylase secretion in yeast†
por: Johansson, S. Andreas, et al.
Publicado: (2023)

CRISPR imaging reveals chromatin fluctuation at the centromere region related to cellular senescence
por: Takata, Hideaki, et al.
Publicado: (2023)

CRISPR-based screening identifies XPO7 as a positive regulator of senescence
por: Li, Lan-Zhu, et al.
Publicado: (2023)

Deciphering essential cistromes using genome-wide CRISPR screens
por: Fei, Teng, et al.
Publicado: (2019)

Development of drug-inducible CRISPR-Cas9 systems for large-scale functional screening
por: Sun, Ning, et al.
Publicado: (2019)

Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens
por: Zernab Hassan, Arshia, et al.
Publicado: (2023)

Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens
por: Hassan, Arshia Zernab, et al.
Publicado: (2023)

Cellular senescence in the aging and diseased kidney
por: Valentijn, F. A., et al.
Publicado: (2017)

Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance
por: Wang, Tianmin, et al.
Publicado: (2018)

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves
por: Liang, Yaru, et al.
Publicado: (2018)

Large scale screening of CRISPR guide RNAs using an optimized high throughput robotics system
por: Spangler, J. R., et al.
Publicado: (2022)

Identification of NCAPG as an Essential Gene for Neuroblastoma Employing CRISPR-Cas9 Screening Database and Experimental Verification
por: Jia, Yubin, et al.
Publicado: (2023)

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
por: Bernadotte, Alexandra, et al.
Publicado: (2016)

Genome-scale CRISPR screening for potential targets of ginsenoside compound K
por: Yang, Yuanyuan, et al.
Publicado: (2020)

Aging, Cellular Senescence, and Alzheimer’s Disease
por: Liu, Rui-Ming
Publicado: (2022)

CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma
por: Li, Ziyi, et al.
Publicado: (2020)

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence
por: Zhou, Zhong-Wei, et al.
Publicado: (2013)

Cellular Senescence in the Treatment of Ovarian Cancer
por: Wang, Zehua, et al.
Publicado: (2018)

Synthetic promoter design in Escherichia coli based on a deep generative network
por: Wang, Ye, et al.
Publicado: (2020)

Cellular senescence in cancer
por: Kim, Young Hwa, et al.
Publicado: (2019)

On the evolution of cellular senescence
por: Kowald, Axel, et al.
Publicado: (2020)

Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen
por: Schepers, Arnout, et al.
Publicado: (2021)

A large-scale genetic screen identifies genes essential for motility in Agrobacterium fabrum
por: Calvopina-Chavez, Diana G., et al.
Publicado: (2023)

The Paradoxical Role of Cellular Senescence in Cancer
por: Yang, Jing, et al.
Publicado: (2021)

Mitochondria organize the cellular proteostatic response and promote cellular senescence
por: Li, Yanjun, et al.
Publicado: (2019)

PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens
por: Lenoir, Walter F, et al.
Publicado: (2018)

Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes
por: Morgens, David W, et al.
Publicado: (2016)

Identification of UBE2I as a Novel Biomarker in ccRCC Based on a Large-Scale CRISPR-Cas9 Screening Database and Immunohistochemistry
por: Li, Feng, et al.
Publicado: (2022)

Cellular Senescence and Periodontitis: Mechanisms and Therapeutics
por: Chen, Sijia, et al.
Publicado: (2022)

Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen
por: Liu, Jie, et al.
Publicado: (2020)

Lrf suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
por: Wang, Guocan, et al.
Publicado: (2013)

Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools
por: Knoppert, Sebastian N., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_co8eccoi0uq9mm29k5asfdps0f