Cargando…

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice

Alzheimer disease (AD) is a neurodegenerative disorder characterized by pathological hallmarks of neurofibrillary tangles and amyloid plaques. The plaques are formed by aggregation and accumulation of amyloid β (Aβ), a cleavage fragment of amyloid precursor protein (APP). Enhanced neuronal activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Ji Soo, Lee, Yeunkum, André, Emily A., Lee, Kea Joo, Nguyen, Thien, Feng, Yang, Jia, Nuo, Harris, Brent T., Burns, Mark P., Pak, Daniel T. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629081/ https://www.ncbi.nlm.nih.gov/pubmed/31306446 http://dx.doi.org/10.1371/journal.pone.0219691

Ejemplares similares

Putting a bit into the polo-box domain of polo-like kinase 1
por: Park, Jung-Eun, et al.
Publicado: (2015)

Loss of Polo ameliorates APP-induced Alzheimer’s disease-like symptoms in Drosophila
por: Peng, Fei, et al.
Publicado: (2015)

Polo-like kinase in trypanosomes: an odd member out of the Polo family
por: Kurasawa, Yasuhiro, et al.
Publicado: (2020)

Polo-like kinase-1 in DNA damage response
por: Hyun, Sun-Yi, et al.
Publicado: (2014)

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
por: Yun, Sang-Moon, et al.
Publicado: (2009)

Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation
por: Lee, Jin-Kwan, et al.
Publicado: (2018)

Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease
por: Song, Bing, et al.
Publicado: (2011)

Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1
por: Murugan, Ravichandran N., et al.
Publicado: (2013)

The balance of Polo-like kinase 1 in tumorigenesis
por: Lu, Lin-Yu, et al.
Publicado: (2009)

The CINs of Polo-Like Kinase 1 in Cancer
por: Cunningham, Chelsea E., et al.
Publicado: (2020)

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1
por: Srinivasrao, Ganipisetti, et al.
Publicado: (2014)

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening
por: Abdelfatah, Sara, et al.
Publicado: (2018)

Polo-like kinase 1 as target for cancer therapy
por: Weiß, Lily, et al.
Publicado: (2012)

Playing POLO-like kinase in NRAS mutant melanoma
por: Chen, Hsin-Yi, et al.
Publicado: (2015)

Role for polo-like kinase 4 in mediation of cytokinesis
por: Press, Michael F., et al.
Publicado: (2019)

Polo-Like Kinase 2: From Principle to Practice
por: Zhang, Chuanyong, et al.
Publicado: (2022)

Polo-like kinase 1 promotes pulmonary hypertension
por: Chen, Rongrong, et al.
Publicado: (2023)

Mitosis-specific phosphorylation of Mis18α by Aurora B kinase enhances kinetochore recruitment of polo-like kinase 1
por: Lee, Minkyoung, et al.
Publicado: (2017)

Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain
por: Chen, Yunyu, et al.
Publicado: (2016)

Drosophila Polo Kinase Is Required for Cytokinesis
por: Carmena, Mar, et al.
Publicado: (1998)

Polo kinase: the choreographer of the mitotic stage?
Publicado: (1996)

Regulation of the polo kinase during cytokinesis
por: Kachaner, David
Publicado: (2015)

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
por: Park, Jung-Eun, et al.
Publicado: (2019)

Polo-Like Kinase Controls Vertebrate Spindle Elongation and Cytokinesis
por: Brennan, Ian M., et al.
Publicado: (2007)

Polo-like kinase 4: the odd one out of the family
por: Sillibourne, James E, et al.
Publicado: (2010)

Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
por: Xu, Dazhong, et al.
Publicado: (2012)

Enhanced polo-like kinase 1 expression in myelodysplastic syndromes
por: Min, Kyoung Il, et al.
Publicado: (2019)

Therapeutic inhibition of polo‐like kinases in anaplastic thyroid cancer
por: Lin, Shu‐Fu, et al.
Publicado: (2021)

Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles
por: Salim, Aleksandar, et al.
Publicado: (2023)

Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents
por: Park, Jung-Eun, et al.
Publicado: (2017)

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry()
por: Lee, Kyung-Jong, et al.
Publicado: (2015)

Polo-Like Kinases (Plks), a Key Regulator of Cell Cycle and New Potential Target for Cancer Therapy
por: Lee, Su-Yeon, et al.
Publicado: (2014)

Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer
por: Oh, Hyunseung, et al.
Publicado: (2022)

Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe
por: Li, Jingjing, et al.
Publicado: (2015)

Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora Kinase and Polo-like Kinase Inhibitors
por: Jadhav, Mrunal, et al.
Publicado: (2021)

Mitotic spindle formation in the absence of Polo kinase
por: Kim, Juyoung, et al.
Publicado: (2022)

Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization
por: Jia, Jia-Lin, et al.
Publicado: (2015)

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
por: Abdelfatah, Sara, et al.
Publicado: (2019)

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
por: Huggins, David J., et al.
Publicado: (2019)

Upregulated Polo-Like Kinase 1 Expression Correlates with Inferior Survival Outcomes in Rectal Cancer
por: Tut, T. G., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cu86cb25c7ltm4oqopc3lc8dpg