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Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors
In humans, the most common epigenetic DNA modification is methylation of the 5-carbon of cytosines, predominantly in CpG dinucleotides. DNA methylation is an important epigenetic mark associated with gene repression. Disruption of the normal DNA methylation pattern is known to play a role in the ini...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629088/ https://www.ncbi.nlm.nih.gov/pubmed/31306451 http://dx.doi.org/10.1371/journal.pone.0219830 |