Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk. We address how cytoplasmic and axonemal dynein MTBDs bind mic...

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Detalles Bibliográficos
Autores principales: Lacey, Samuel E, He, Shaoda, Scheres, Sjors HW, Carter, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629372/
https://www.ncbi.nlm.nih.gov/pubmed/31264960
http://dx.doi.org/10.7554/eLife.47145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629372/
https://www.ncbi.nlm.nih.gov/pubmed/31264960
http://dx.doi.org/10.7554/eLife.47145

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