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Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish

Prenatal alcohol exposure is the leading cause of birth defects, collectively termed fetal alcohol spectrum disorders (FASD). In the United States and Canada, 1 in 100 children will be born with FASD. Some of the most commonly debilitating defects of FASD are in social behavior. Zebrafish are highly...

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Autores principales: Fernandes, Yohaan, Rampersad, Mindy, Jones, Emma M., Eberhart, Johann K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629526/
https://www.ncbi.nlm.nih.gov/pubmed/30178621
http://dx.doi.org/10.1111/adb.12649
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author Fernandes, Yohaan
Rampersad, Mindy
Jones, Emma M.
Eberhart, Johann K.
author_facet Fernandes, Yohaan
Rampersad, Mindy
Jones, Emma M.
Eberhart, Johann K.
author_sort Fernandes, Yohaan
collection PubMed
description Prenatal alcohol exposure is the leading cause of birth defects, collectively termed fetal alcohol spectrum disorders (FASD). In the United States and Canada, 1 in 100 children will be born with FASD. Some of the most commonly debilitating defects of FASD are in social behavior. Zebrafish are highly social animals, and embryonic ethanol exposure from 24 to 26 hours post‐fertilization disrupts this social (shoaling) response in adult zebrafish. Recent findings have suggested that social behaviors are present in zebrafish larvae as young as 3 weeks, but how they relate to adult shoaling is unclear. We tested the same ethanol‐exposed zebrafish for social impairments at 3 weeks then again at 16 weeks. At both ages, live conspecifics were used to elicit a social response. We did not find alcohol‐induced differences in behavior in 3‐week‐old fish when they were able to see conspecifics. We do find evidence that control zebrafish are able to use nonvisual stimuli to detect conspecifics, and this behavior is disrupted in the alcohol‐exposed fish. As adults, these fish displayed a significant decrease in social behavior when conspecifics are visible. This surprising finding demonstrates that the adult and larval social behaviors are, at least partly, separable. Future work will investigate the nature of these nonvisual cues and how the neurocircuitry differs between the larval and adult social behaviors.
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spelling pubmed-66295262019-09-01 Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish Fernandes, Yohaan Rampersad, Mindy Jones, Emma M. Eberhart, Johann K. Addict Biol Preclinical Studies Prenatal alcohol exposure is the leading cause of birth defects, collectively termed fetal alcohol spectrum disorders (FASD). In the United States and Canada, 1 in 100 children will be born with FASD. Some of the most commonly debilitating defects of FASD are in social behavior. Zebrafish are highly social animals, and embryonic ethanol exposure from 24 to 26 hours post‐fertilization disrupts this social (shoaling) response in adult zebrafish. Recent findings have suggested that social behaviors are present in zebrafish larvae as young as 3 weeks, but how they relate to adult shoaling is unclear. We tested the same ethanol‐exposed zebrafish for social impairments at 3 weeks then again at 16 weeks. At both ages, live conspecifics were used to elicit a social response. We did not find alcohol‐induced differences in behavior in 3‐week‐old fish when they were able to see conspecifics. We do find evidence that control zebrafish are able to use nonvisual stimuli to detect conspecifics, and this behavior is disrupted in the alcohol‐exposed fish. As adults, these fish displayed a significant decrease in social behavior when conspecifics are visible. This surprising finding demonstrates that the adult and larval social behaviors are, at least partly, separable. Future work will investigate the nature of these nonvisual cues and how the neurocircuitry differs between the larval and adult social behaviors. John Wiley and Sons Inc. 2018-09-04 2019-09 /pmc/articles/PMC6629526/ /pubmed/30178621 http://dx.doi.org/10.1111/adb.12649 Text en © 2018 The Authors.Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Preclinical Studies
Fernandes, Yohaan
Rampersad, Mindy
Jones, Emma M.
Eberhart, Johann K.
Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title_full Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title_fullStr Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title_full_unstemmed Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title_short Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
title_sort social deficits following embryonic ethanol exposure arise in post‐larval zebrafish
topic Preclinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629526/
https://www.ncbi.nlm.nih.gov/pubmed/30178621
http://dx.doi.org/10.1111/adb.12649
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