Cargando…

Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Exposure to maternal diabetes during pregnancy results in diabetes in offspring, but its underlying mechanisms are unclear. Here, we investigated the phenotype and molecular defects of the offspring of poorly controlled diabetic female mice generated by streptozotocin (STZ) administration. Offspring...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inoguchi, Yukihiro, Ichiyanagi, Kenji, Ohishi, Hiroaki, Maeda, Yasutaka, Sonoda, Noriyuki, Ogawa, Yoshihiro, Inoguchi, Toyoshi, Sasaki, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629688/ https://www.ncbi.nlm.nih.gov/pubmed/31308441 http://dx.doi.org/10.1038/s41598-019-46638-2

Ejemplares similares

Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells
por: Maki, Toshinobu, et al.
Publicado: (2019)

Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study
por: Abe, Kentaro, et al.
Publicado: (2021)

Association of serum total bilirubin levels with progressive renal decline and end-stage kidney disease: 10-year observational cohort study in Japanese patients with diabetes
por: Eto, Erina, et al.
Publicado: (2022)

Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control
por: Inoue, Tomoaki, et al.
Publicado: (2016)

Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes
por: Kudo, Kana, et al.
Publicado: (2021)

Serum Bilirubin Concentration is Associated with Left Ventricular Remodeling in Patients with Type 2 Diabetes Mellitus: A Cohort Study
por: Inoue, Tomoaki, et al.
Publicado: (2018)

Aberrant activation of bone marrow Ly6C (high) monocytes in diabetic mice contributes to impaired glucose tolerance
por: Ikeda, Yosuke, et al.
Publicado: (2020)

Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
por: Takei, Ryoko, et al.
Publicado: (2019)

p66Shc Signaling Mediates Diabetes-Related Cognitive Decline
por: Minami, Yohei, et al.
Publicado: (2018)

The Role of Oxidative Stress in the Pathogenesis of Diabetic Vascular Complications
por: Sasaki, Shuji, et al.
Publicado: (2012)

Clinical significance of barriers to blood glucose control in type 2 diabetes patients with insufficient glycemic control
por: Suzuki, Takeo, et al.
Publicado: (2015)

Relationship between serum indirect bilirubin levels and skeletal muscle mass in older male and female patients with type 2 diabetes
por: Inoguchi, Yukihiro, et al.
Publicado: (2022)

Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus
por: Takayanagi, Ryoichi, et al.
Publicado: (2011)

The dipeptidyl peptidase-4 inhibitor, linagliptin, improves cognitive impairment in streptozotocin-induced diabetic mice by inhibiting oxidative stress and microglial activation
por: Ide, Makoto, et al.
Publicado: (2020)

Association of serum bilirubin levels with risk of cancer development and total death
por: Inoguchi, Toyoshi, et al.
Publicado: (2021)

Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency
por: Kobayashi, Masahiro, et al.
Publicado: (2017)

Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4‐associated oxidative stress in diabetic hamsters
por: Maeda, Yasutaka, et al.
Publicado: (2012)

Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes
por: Yamato, Mayumi, et al.
Publicado: (2020)

A simplified prediction model for end-stage kidney disease in patients with diabetes
por: Inoguchi, Toyoshi, et al.
Publicado: (2022)

Serum bilirubin level is a strong predictor for disability in activities in daily living (ADL) in Japanese elderly patients with diabetes
por: Inoguchi, Toyoshi, et al.
Publicado: (2019)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
por: Ichiyanagi, Tomoko, et al.
Publicado: (2013)

HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse
por: Ichiyanagi, Tomoko, et al.
Publicado: (2014)

Hepatic IGF2/H19 Epigenetic Alteration Induced Glucose Intolerance in Gestational Diabetes Mellitus Offspring via FoxO1 Mediation
por: Jiang, Ying, et al.
Publicado: (2022)

FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells
por: Tsuji, Toshikatsu, et al.
Publicado: (2021)

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization
por: Kikuchi, Osamu, et al.
Publicado: (2012)

The relationship between trust in mass media and the healthcare system and individual health: evidence from the AsiaBarometer Survey
por: Tokuda, Yasuharu, et al.
Publicado: (2009)

Hereditary Hemorrhagic Telangiectasia with SMAD4 Mutations Is Associated with Fatty Degeneration of the Left Ventricle, Coronary Artery Aneurysm, and Abdominal Aortic Aneurysm
por: Inoguchi, Yasunori, et al.
Publicado: (2018)

Atypical Aortic Coarctation in a Patient with an Acute Exacerbation of Multiple Organ Failure: Successful Endovascular Therapy and Spontaneous Retroperitoneal Bleeding
por: Inoguchi, Yasunori, et al.
Publicado: (2020)

A Rare Case of Pelvic Abscess Due to Spontaneous Non-traumatic Bladder Rupture
por: Inoguchi, Kyosuke, et al.
Publicado: (2021)

Diverse sensitivities of TRPA1 from different mosquito species to thermal and chemical stimuli
por: Li, Tianbang, et al.
Publicado: (2019)

3D-TTN: a power efficient cost effective high performance hierarchical interconnection network for next generation green supercomputer
por: Faisal, Faiz Al, et al.
Publicado: (2021)

Gestational and Lactational Co-Exposure to DEHP and BPA Impairs Hepatic Function via PI3K/AKT/FOXO1 Pathway in Offspring
por: Wang, Minghan, et al.
Publicado: (2023)

Interpersonal Trust and Quality-of-Life: A Cross-Sectional Study in Japan
por: Tokuda, Yasuharu, et al.
Publicado: (2008)

Hypoallergenic Wheat Line (1BS-18H) Lacking ω5-Gliadin Induces Oral Tolerance to Wheat Gluten Proteins in a Rat Model of Wheat Allergy
por: Yamada, Yukinori, et al.
Publicado: (2022)

Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52‐week data from the PROVIDE study
por: Araki, Eiichi, et al.
Publicado: (2019)

Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites
por: Shimosuga, Ken-ichi, et al.
Publicado: (2017)

Is Arsenic “Lactation Intolerant”?: Study Indicates Low Excretion in Breast Milk
por: Tillett, Tanya
Publicado: (2008)

Reactivity of Zinc Cations under Spontaneous Accumulation of Hydrophobic Coexisting Cations in Hydrophobic Nanoporous Silicon
por: Inoguchi, Shota, et al.
Publicado: (2020)

Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation
por: Fujita, Yuko, et al.
Publicado: (2020)

Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
por: Wu, Xiumei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7iskg266m3jqrbrepk2l5cv2co