Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms

Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evaluated in the UK Biobank, we identify 38 associated...

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Detalles Bibliográficos
Autores principales: Emami, Nima C., Kachuri, Linda, Meyers, Travis J., Das, Rajdeep, Hoffman, Joshua D., Hoffmann, Thomas J., Hu, Donglei, Shan, Jun, Feng, Felix Y., Ziv, Elad, Van Den Eeden, Stephen K., Witte, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629701/
https://www.ncbi.nlm.nih.gov/pubmed/31308362
http://dx.doi.org/10.1038/s41467-019-10808-7

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