Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

Anticancer chemotherapeutic drugs mainly trigger apoptosis induction to eliminate malignant cells. However, many cancer cells are chemoresistant because of defective apoptosis induction. Targeting the autophagic pathway is currently regarded as an alternative strategy for cancer drug discovery. Penf...

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Detalles Bibliográficos
Autores principales: Hung, Wen-Yueh, Chang, Jer-Hwa, Cheng, Yu, Cheng, Guo-Zhou, Huang, Hsiang-Ching, Hsiao, Michael, Chung, Chi-Li, Lee, Wei-Jiunn, Chien, Ming-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629704/
https://www.ncbi.nlm.nih.gov/pubmed/31308361
http://dx.doi.org/10.1038/s41419-019-1785-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629704/
https://www.ncbi.nlm.nih.gov/pubmed/31308361
http://dx.doi.org/10.1038/s41419-019-1785-9

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