Radionuclide generator-based production of therapeutic (177)Lu from its long-lived isomer (177m)Lu

BACKGROUND: In this work, a lutetium-177 ((177)Lu) production method based on the separation of nuclear isomers, (177m)Lu & (177)Lu, is reported. The (177m)Lu-(177)Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. METHODS...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Rupali, Wolterbeek, Hubert Th., Denkova, Antonia G., Serra-Crespo, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629729/
https://www.ncbi.nlm.nih.gov/pubmed/31659496
http://dx.doi.org/10.1186/s41181-019-0064-5

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