Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics

The Sleeping Beauty (SB) transposon insertional mutagenesis system offers a streamlined approach to identify genetic drivers of cancer. With a relatively random insertion profile, SB is uniquely positioned for conducting unbiased forward genetic screens. Indeed, SB mouse models of cancer have reveal...

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Detalles Bibliográficos
Autores principales: Guimaraes-Young, Amy, Feddersen, Charlotte R., Dupuy, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629774/
https://www.ncbi.nlm.nih.gov/pubmed/31338332
http://dx.doi.org/10.3389/fonc.2019.00611
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author Guimaraes-Young, Amy
Feddersen, Charlotte R.
Dupuy, Adam J.
author_facet Guimaraes-Young, Amy
Feddersen, Charlotte R.
Dupuy, Adam J.
author_sort Guimaraes-Young, Amy
collection PubMed
description The Sleeping Beauty (SB) transposon insertional mutagenesis system offers a streamlined approach to identify genetic drivers of cancer. With a relatively random insertion profile, SB is uniquely positioned for conducting unbiased forward genetic screens. Indeed, SB mouse models of cancer have revealed insights into the genetics of tumorigenesis. In this review, we highlight experiments that have exploited the SB system to interrogate the genetics of cancer in distinct biological contexts. We also propose experimental designs that could further our understanding of the relationship between tumor microenvironment and tumor progression.
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spelling pubmed-66297742019-07-23 Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics Guimaraes-Young, Amy Feddersen, Charlotte R. Dupuy, Adam J. Front Oncol Oncology The Sleeping Beauty (SB) transposon insertional mutagenesis system offers a streamlined approach to identify genetic drivers of cancer. With a relatively random insertion profile, SB is uniquely positioned for conducting unbiased forward genetic screens. Indeed, SB mouse models of cancer have revealed insights into the genetics of tumorigenesis. In this review, we highlight experiments that have exploited the SB system to interrogate the genetics of cancer in distinct biological contexts. We also propose experimental designs that could further our understanding of the relationship between tumor microenvironment and tumor progression. Frontiers Media S.A. 2019-07-09 /pmc/articles/PMC6629774/ /pubmed/31338332 http://dx.doi.org/10.3389/fonc.2019.00611 Text en Copyright © 2019 Guimaraes-Young, Feddersen and Dupuy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Guimaraes-Young, Amy
Feddersen, Charlotte R.
Dupuy, Adam J.
Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title_full Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title_fullStr Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title_full_unstemmed Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title_short Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
title_sort sleeping beauty mouse models of cancer: microenvironmental influences on cancer genetics
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629774/
https://www.ncbi.nlm.nih.gov/pubmed/31338332
http://dx.doi.org/10.3389/fonc.2019.00611
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